PDF(Pubmed)
Abstract：
BACKGROUND: Cluster headache (CH) is associated with high disability. The Cluster Headache Impact Questionnaire (CHIQ) is a short, disease-specific disability questionnaire first developed and validated in German. Here, we validated the English version of this questionnaire.
METHODS: The CHIQ was assessed together with nonspecific headache-related disability questionnaires in CH patients from a tertiary headache center and an American self-help group.
RESULTS: 155 active episodic and chronic CH patients were included. The CHIQ showed good internal consistency (Cronbach\'s α = 0.91) and test-retest reliability (ICC = 0.93, n = 44). Factor analysis identified a single factor. Convergent validity was shown by significant correlations with the Headache Impact Test™ (HIT-6™, ρ = 0.72, p < 0.001), the Hospital Anxiety and Depression Scale (HADS depression: ρ = 0.53, HADS anxiety: ρ = 0.61, both p < 0.001), the Perceived Stress Scale (PSS-10, ρ = 0.61, p < 0.001) and with CH attack frequency (ρ = 0.29, p < 0.001). Chronic CH patients showed the highest CHIQ scores (25.4 ± 7.9, n = 76), followed by active episodic CH and episodic CH patients in remission (active eCH: 22.2 ± 8.7, n = 79; eCH in remission: 14.1 ± 13.1, n = 127; p < 0.001). Furthermore, the CHIQ was graded into 5 levels from \"no to low impact\" to \"extreme impact\" based on the patients\' perception. Higher CHIQ grading was associated with higher attack and acute medication frequency, HIT-6™, HADS and PSS scores.
CONCLUSIONS: The English version of the CHIQ is a reliable, valid, and disease-specific patient-reported outcome measure to assess the impact of headaches on CH patients.
METHODS: The CHIQ was assessed together with nonspecific headache-related disability questionnaires in CH patients from a tertiary headache center and an American self-help group.
RESULTS: 155 active episodic and chronic CH patients were included. The CHIQ showed good internal consistency (Cronbach\'s α = 0.91) and test-retest reliability (ICC = 0.93, n = 44). Factor analysis identified a single factor. Convergent validity was shown by significant correlations with the Headache Impact Test™ (HIT-6™, ρ = 0.72, p < 0.001), the Hospital Anxiety and Depression Scale (HADS depression: ρ = 0.53, HADS anxiety: ρ = 0.61, both p < 0.001), the Perceived Stress Scale (PSS-10, ρ = 0.61, p < 0.001) and with CH attack frequency (ρ = 0.29, p < 0.001). Chronic CH patients showed the highest CHIQ scores (25.4 ± 7.9, n = 76), followed by active episodic CH and episodic CH patients in remission (active eCH: 22.2 ± 8.7, n = 79; eCH in remission: 14.1 ± 13.1, n = 127; p < 0.001). Furthermore, the CHIQ was graded into 5 levels from \"no to low impact\" to \"extreme impact\" based on the patients\' perception. Higher CHIQ grading was associated with higher attack and acute medication frequency, HIT-6™, HADS and PSS scores.
CONCLUSIONS: The English version of the CHIQ is a reliable, valid, and disease-specific patient-reported outcome measure to assess the impact of headaches on CH patients.
摘要：
背景：丛集性头痛（CH）与高残疾有关。集群头痛影响问卷(CHIQ)是一个简短的，疾病特异性残疾问卷最初以德语开发和验证。这里,我们验证了这份问卷的英文版。
方法：在三级头痛中心和美国自助小组的CH患者中，对CHIQ与非特异性头痛相关残疾问卷进行了评估。
结果：纳入了155名活动性发作性和慢性CH患者。CHIQ表现出良好的内部一致性（Cronbach'sα=0.91）和重测可靠性（ICC=0.93，n=44）。因子分析确定了一个单一因素。与头痛冲击测试™(HIT-6™，ρ=0.72，p<0.001)，医院焦虑和抑郁量表（HADS抑郁：ρ=0.53，HADS焦虑：ρ=0.61，均p<0.001），感知压力量表(PSS-10，ρ=0.61，p<0.001)和CH攻击频率(ρ=0.29，p<0.001)。慢性CH患者的CHIQ得分最高（25.4±7.9，n=76），其次是活动性发作性CH和缓解期CH患者（活动性eCH：22.2±8.7，n=79；缓解期eCH：14.1±13.1，n=127；p<0.001）。此外，根据患者的感知，CHIQ分为5级，从“无影响到低影响”到“极端影响”。较高的CHIQ分级与较高的发作和急性用药频率相关，HIT-6™,HADS和PSS评分。
结论：CHIQ的英文版是可靠的，有效,和特定疾病患者报告的结局指标，以评估头痛对CH患者的影响。
方法：在三级头痛中心和美国自助小组的CH患者中，对CHIQ与非特异性头痛相关残疾问卷进行了评估。
结果：纳入了155名活动性发作性和慢性CH患者。CHIQ表现出良好的内部一致性（Cronbach'sα=0.91）和重测可靠性（ICC=0.93，n=44）。因子分析确定了一个单一因素。与头痛冲击测试™(HIT-6™，ρ=0.72，p<0.001)，医院焦虑和抑郁量表（HADS抑郁：ρ=0.53，HADS焦虑：ρ=0.61，均p<0.001），感知压力量表(PSS-10，ρ=0.61，p<0.001)和CH攻击频率(ρ=0.29，p<0.001)。慢性CH患者的CHIQ得分最高（25.4±7.9，n=76），其次是活动性发作性CH和缓解期CH患者（活动性eCH：22.2±8.7，n=79；缓解期eCH：14.1±13.1，n=127；p<0.001）。此外，根据患者的感知，CHIQ分为5级，从“无影响到低影响”到“极端影响”。较高的CHIQ分级与较高的发作和急性用药频率相关，HIT-6™,HADS和PSS评分。
结论：CHIQ的英文版是可靠的，有效,和特定疾病患者报告的结局指标，以评估头痛对CH患者的影响。
