METHODS: The CHIQ was assessed together with nonspecific headache-related disability questionnaires in CH patients from a tertiary headache center and an American self-help group.
RESULTS: 155 active episodic and chronic CH patients were included. The CHIQ showed good internal consistency (Cronbach\'s α = 0.91) and test-retest reliability (ICC = 0.93, n = 44). Factor analysis identified a single factor. Convergent validity was shown by significant correlations with the Headache Impact Test™ (HIT-6™, ρ = 0.72, p < 0.001), the Hospital Anxiety and Depression Scale (HADS depression: ρ = 0.53, HADS anxiety: ρ = 0.61, both p < 0.001), the Perceived Stress Scale (PSS-10, ρ = 0.61, p < 0.001) and with CH attack frequency (ρ = 0.29, p < 0.001). Chronic CH patients showed the highest CHIQ scores (25.4 ± 7.9, n = 76), followed by active episodic CH and episodic CH patients in remission (active eCH: 22.2 ± 8.7, n = 79; eCH in remission: 14.1 ± 13.1, n = 127; p < 0.001). Furthermore, the CHIQ was graded into 5 levels from \"no to low impact\" to \"extreme impact\" based on the patients\' perception. Higher CHIQ grading was associated with higher attack and acute medication frequency, HIT-6™, HADS and PSS scores.
CONCLUSIONS: The English version of the CHIQ is a reliable, valid, and disease-specific patient-reported outcome measure to assess the impact of headaches on CH patients.
方法:在三级头痛中心和美国自助小组的CH患者中,对CHIQ与非特异性头痛相关残疾问卷进行了评估。
结果:纳入了155名活动性发作性和慢性CH患者。CHIQ表现出良好的内部一致性(Cronbach'sα=0.91)和重测可靠性(ICC=0.93,n=44)。因子分析确定了一个单一因素。与头痛冲击测试™(HIT-6™,ρ=0.72,p<0.001),医院焦虑和抑郁量表(HADS抑郁:ρ=0.53,HADS焦虑:ρ=0.61,均p<0.001),感知压力量表(PSS-10,ρ=0.61,p<0.001)和CH攻击频率(ρ=0.29,p<0.001)。慢性CH患者的CHIQ得分最高(25.4±7.9,n=76),其次是活动性发作性CH和缓解期CH患者(活动性eCH:22.2±8.7,n=79;缓解期eCH:14.1±13.1,n=127;p<0.001)。此外,根据患者的感知,CHIQ分为5级,从“无影响到低影响”到“极端影响”。较高的CHIQ分级与较高的发作和急性用药频率相关,HIT-6™,HADS和PSS评分。
结论:CHIQ的英文版是可靠的,有效,和特定疾病患者报告的结局指标,以评估头痛对CH患者的影响。