利用 HSP70 介导的蛋白质周转的 N - Myc 的蛋白质停滞扰动改善了神经内分泌前列腺癌的治疗。
Mesh : Male Humans Prostatic Neoplasms / metabolism drug therapy pathology genetics HSP70 Heat-Shock Proteins / metabolism Ubiquitin-Protein Ligases / metabolism genetics Ubiquitination / drug effects Cell Line, Tumor Proteostasis Animals Aurora Kinase A / metabolism genetics antagonists & inhibitors N-Myc Proto-Oncogene Protein / metabolism genetics Mice Carcinoma, Neuroendocrine / metabolism genetics drug therapy pathology Neuroendocrine Tumors / metabolism drug therapy genetics pathology
来 源:
DOI:10.1038/s41467-024-50459-x
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