Abstract：
The treatment of thoracic tumors with ionizing radiation can cause radiation-induced lung injury (RILI), which includes radiation pneumonitis and radiation-induced pulmonary fibrosis. Preventing RILI is crucial for controlling tumor growth and improving quality of life. However, the serious adverse effects of traditional RILI treatment methods remain a major obstacle, necessitating the development of novel treatment options that are both safe and effective. This review summarizes the molecular mechanisms of RILI and explores novel treatment options, including natural compounds, gene therapy, nanomaterials, and mesenchymal stem cells. These recent experimental approaches show potential as effective prevention and treatment options for RILI in clinical practice.
摘要：
用电离辐射治疗胸部肿瘤可引起放射性肺损伤（RILI），其中包括放射性肺炎和放射性肺纤维化。预防RILI对于控制肿瘤生长和改善生活质量至关重要。然而,传统RILI治疗方法的严重不良反应仍然是主要障碍，需要开发既安全又有效的新型治疗方案。这篇综述总结了RILI的分子机制，并探讨了新的治疗方案。包括天然化合物,基因治疗,纳米材料，和间充质干细胞。这些最近的实验方法显示了在临床实践中作为RILI的有效预防和治疗选择的潜力。
