Abstract：
BACKGROUND: Zika virus (ZIKV) stands as one of the most significant reemerging viral pathogens, linked to neurological diseases such as meningoencephalitis and congenital microcephaly. Today there are no effective therapies for treating ZIKV-infected patients. MiRNAs play a critical role in regulating cellular signaling and physiological conditions, and alterations in their profiles can bear great significance in disease progression.
OBJECTIVE: Despite significant progress in understanding the interaction between the ZIKV and its host since the outbreak, a more comprehensive understanding on these interactions is imperative. This review aims to summarize the studies in the field and shed light on the intricate relationship between ZIKV and its host at the molecular level.
BACKGROUND: We found that in ZIKV-infected humans, over-expression of miR-431-5p and miR-30e-5p plays a crucial role in innate immune responses and contributes to neurological damage. Additionally, in ZIKA-infected mice, we observed upregulated expression of all the targets of miR-124-3p including CCL2, IL7, IRF1, and SBNO2. Notably, other targets of this miRNA include TLR6, TNF, STAT3, and NF-kB also exhibited upregulation in the central nervous system (CNS) of infected mice. Conversely, miR-654-3p levels were reduced, correlating with the upregulation of its predicted targets including FLT3LG, LITAF, CD69, and TLR2. In the case of insects, aae-miR-286a/b-3p was predicted to target all ZIKV genotypes. This specific miRNA is typically found in ovaries and can be transferred to embryos. In conclusion, our findings suggest that host microRNAs and ZIKV-encoded microRNAs hold promise as potential targets for the diagnosis of ZIKV infections and may even serve as a therapeutic approach for managing this infectious disease.
OBJECTIVE: Despite significant progress in understanding the interaction between the ZIKV and its host since the outbreak, a more comprehensive understanding on these interactions is imperative. This review aims to summarize the studies in the field and shed light on the intricate relationship between ZIKV and its host at the molecular level.
BACKGROUND: We found that in ZIKV-infected humans, over-expression of miR-431-5p and miR-30e-5p plays a crucial role in innate immune responses and contributes to neurological damage. Additionally, in ZIKA-infected mice, we observed upregulated expression of all the targets of miR-124-3p including CCL2, IL7, IRF1, and SBNO2. Notably, other targets of this miRNA include TLR6, TNF, STAT3, and NF-kB also exhibited upregulation in the central nervous system (CNS) of infected mice. Conversely, miR-654-3p levels were reduced, correlating with the upregulation of its predicted targets including FLT3LG, LITAF, CD69, and TLR2. In the case of insects, aae-miR-286a/b-3p was predicted to target all ZIKV genotypes. This specific miRNA is typically found in ovaries and can be transferred to embryos. In conclusion, our findings suggest that host microRNAs and ZIKV-encoded microRNAs hold promise as potential targets for the diagnosis of ZIKV infections and may even serve as a therapeutic approach for managing this infectious disease.
摘要：
背景：寨卡病毒（ZIKV）是最重要的复发病毒病原体之一，与脑膜脑炎和先天性小头畸形等神经系统疾病有关。目前还没有治疗ZIKV感染患者的有效疗法。miRNAs在调节细胞信号和生理条件中起关键作用，并且其特征的改变在疾病进展中具有重要意义。
目的：尽管在了解ZIKV与宿主之间的相互作用方面取得了重大进展，必须对这些相互作用有更全面的了解。本文旨在总结该领域的研究，并在分子水平上阐明ZIKV与其宿主之间的复杂关系。
背景：我们发现在ZIKV感染的人类中，miR-431-5p和miR-30e-5p的过表达在先天免疫反应中起着至关重要的作用,并有助于神经损伤。此外,在ZIKA感染的小鼠中，我们观察到miR-124-3p的所有靶标的表达上调,包括CCL2,IL7,IRF1和SBNO2.值得注意的是,该miRNA的其他靶标包括TLR6，TNF，STAT3和NF-kB在感染小鼠的中枢神经系统(CNS)中也表现出上调。相反，miR-654-3p水平降低，与包括FLT3LG在内的预测目标的上调相关，LITAF,CD69和TLR2。在昆虫的情况下，预测aae-miR-286a/b-3p靶向所有ZIKV基因型。这种特定的miRNA通常存在于卵巢中，可以转移到胚胎中。总之,我们的研究结果表明,宿主microRNAs和ZIKV编码的microRNAs有望成为ZIKV感染诊断的潜在靶点,甚至可以作为管理这种感染性疾病的治疗方法.
目的：尽管在了解ZIKV与宿主之间的相互作用方面取得了重大进展，必须对这些相互作用有更全面的了解。本文旨在总结该领域的研究，并在分子水平上阐明ZIKV与其宿主之间的复杂关系。
背景：我们发现在ZIKV感染的人类中，miR-431-5p和miR-30e-5p的过表达在先天免疫反应中起着至关重要的作用,并有助于神经损伤。此外,在ZIKA感染的小鼠中，我们观察到miR-124-3p的所有靶标的表达上调,包括CCL2,IL7,IRF1和SBNO2.值得注意的是,该miRNA的其他靶标包括TLR6，TNF，STAT3和NF-kB在感染小鼠的中枢神经系统(CNS)中也表现出上调。相反，miR-654-3p水平降低，与包括FLT3LG在内的预测目标的上调相关，LITAF,CD69和TLR2。在昆虫的情况下，预测aae-miR-286a/b-3p靶向所有ZIKV基因型。这种特定的miRNA通常存在于卵巢中，可以转移到胚胎中。总之,我们的研究结果表明,宿主microRNAs和ZIKV编码的microRNAs有望成为ZIKV感染诊断的潜在靶点,甚至可以作为管理这种感染性疾病的治疗方法.
