Abstract：
UNASSIGNED: Amyloidosis is a protein misfolding disorder characterized by the extracellular deposition of insoluble amyloid fibrils, derived from abnormally folded proteins. These fibrils disrupt tissue structure and function, leading to organ dysfunction. The condition encompasses various subtypes, each associated with distinct precursor proteins and clinical manifestations. 99mTc-PYP scintigraphy is used widely and holds significant importance for diagnosis. 68Ga-FAPI is also a promising radiotracer for various diseases. To our knowledge, this is the first case of a patient with hereditary transthyretin amyloidosis with cardiac involvement, which FAPI PET showed diffuse increased myocardial uptake.
摘要：
■淀粉样变是一种蛋白质错误折叠障碍，其特征是不溶性淀粉样纤维的细胞外沉积，来自异常折叠的蛋白质。这些原纤维破坏组织结构和功能，导致器官功能障碍.该条件包括各种亚型，每种都与不同的前体蛋白和临床表现相关。99mTc-PYP闪烁显像被广泛使用，对诊断具有重要意义。68Ga-FAPI也是用于各种疾病的有前途的放射性示踪剂。据我们所知,这是首例遗传性甲状腺素运载蛋白淀粉样变性伴心脏受累的患者，其中FAPIPET显示弥漫性心肌摄取增加。
