Abstract：
In recent years, significant advancements have been made in understanding Alzheimer\'s disease from both neurobiological and clinical perspectives. Exploring the complex systems underlying AD has unveiled insights that could potentially revolutionize therapeutic approaches. Recent investigations have highlighted intricate interactions among genetic, molecular, and environmental factors in AD. Optimism arises from neurobiological advancements and diverse treatment options, potentially slowing or halting disease progression. Amyloid-beta plaques and tau protein tangles crucially influence AD onset and progression. Emerging treatments involve diverse strategies, such as approaches targeting multiple pathways involved in AD pathogenesis, such as inflammation, oxidative stress, and synaptic dysfunction pathways. Clinical trials using humanized monoclonal antibodies, focusing on immunotherapies eliminating amyloid-beta, have shown promise. Nonpharmacological interventions such as light therapy, electrical stimulation, cognitive training, physical activity, and dietary changes have drawn attention for their potential to slow cognitive aging and enhance brain health. Precision medicine, which involves tailoring therapies to individual genetic and molecular profiles, has gained traction. Ongoing research and interdisciplinary collaboration are expected to yield more effective treatments.
摘要：
近年来,在从神经生物学和临床角度理解阿尔茨海默病方面取得了重大进展。探索AD背后的复杂系统揭示了可能彻底改变治疗方法的见解。最近的调查强调了基因之间复杂的相互作用，分子，和环境因素在AD中的作用。乐观来自神经生物学的进步和不同的治疗选择，可能减缓或停止疾病进展。淀粉样蛋白-β斑块和tau蛋白缠结对AD的发病和进展有重要影响.新兴治疗涉及不同的策略，如针对涉及AD发病机制的多个途径的方法，比如炎症，氧化应激，和突触功能障碍通路。使用人源化单克隆抗体的临床试验，专注于消除β淀粉样蛋白的免疫疗法，显示出了希望。非药物干预措施，如光疗，电刺激,认知训练,身体活动,饮食变化引起了人们的注意，因为它们有可能减缓认知衰老和增强大脑健康。精准医学,这包括根据个体的遗传和分子特征定制治疗方法，获得了牵引力。正在进行的研究和跨学科合作有望产生更有效的治疗方法。
