Abstract：
Obesity is a widespread prevailing health concern with multifactorial causes. Among the various defined molecular targets associated with obesity, peroxisome proliferator activated receptor gamma, leptin, ghrelin, and adiponectin play crucial roles in fundamental processes including energy balance, adipose tissue biology, and metabolic health, making them particularly significant in the study of obesity.Capsaicin and orange peel exhibit promising anti-obesity properties through their thermogenic, metabolic, and anti-inflammatory effects. Potential pathways for therapeutic approaches in the management of obesity are provided by these targets. The lipid-lowering and anti-obesity benefits of specific plant species have been highlighted in Asian medicine. Due to the potential anti-obesity qualities, capsaicin, which is derived from chilli peppers, and orange peel extract has been focused in this review. Capsaicin causes apoptosis in preadipocytes and adipocytes and suppresses adipogenesis. Citrus fruits are a significant source of bioactive substances, primarily flavonoids. Due to their ability to reduce adipocyte development and cellular lipid content, citrus polyphenols are helpful in the control of obesity. This extensive analysis offers insights into new treatment approaches for the prevention and management of obesity and metabolic syndrome by examining the interactions of molecular variables in obesity as well as the possible anti-obesity advantages of capsaicin and orange peel extract.
摘要：
肥胖是一种普遍存在的健康问题，具有多种因素。在与肥胖相关的各种定义的分子靶标中，过氧化物酶体增殖物激活受体γ，瘦素,ghrelin,脂联素在包括能量平衡在内的基本过程中起着至关重要的作用，脂肪组织生物学，和代谢健康，使它们在肥胖研究中特别重要。辣椒素和橘皮通过其热产生表现出有希望的抗肥胖特性，新陈代谢，和抗炎作用。这些靶标提供了治疗肥胖的治疗方法的潜在途径。亚洲医学已经强调了特定植物物种的降脂和抗肥胖益处。由于潜在的抗肥胖品质，辣椒素,它来自辣椒，橘皮提取物是本文的重点。辣椒素引起前脂肪细胞和脂肪细胞的凋亡并抑制脂肪生成。柑橘类水果是生物活性物质的重要来源，主要是类黄酮。由于它们能够减少脂肪细胞发育和细胞脂质含量，柑橘多酚有助于控制肥胖。通过研究肥胖中分子变量的相互作用以及辣椒素和橘皮提取物可能的抗肥胖优势，这项广泛的分析为预防和管理肥胖和代谢综合征的新治疗方法提供了见解。
