Abstract：
As a form of dementia, Alzheimer\'s disease (AD) suffers from no efficacious cure, yet AD treatment is still imperative, as it ameliorates the symptoms or prevents it from deteriorating or maintains the current status to the longest extent. The human brain is the most sensitive and complex organ in the body, which is protected by the blood-brain barrier (BBB). This yet induces the difficulty in curing AD as the drugs or nanomaterials that are much inhibited from reaching the lesion site. Thus, BBB crossing capability of drug delivery system remains a significant challenge in the development of neurological therapeutics. Fortunately, nano-enabled delivery systems possess promising potential to achieve multifunctional diagnostics/therapeutics against various targets of AD owing to their intriguing advantages of nanocarriers, including easy multifunctionalization on surfaces, high surface-to-volume ratio with large payloads, and potential ability to cross the BBB, making them capable of conquering the limitations of conventional drug candidates. This review, which focuses on the BBB crossing ability of the multifunctional nanomaterials in AD diagnosis and treatment, will provide an insightful vision that is conducive to the development of AD-related nanomaterials.
摘要：
作为痴呆症的一种形式，阿尔茨海默病（AD）没有有效的治疗方法，然而，AD治疗仍然势在必行，因为它可以改善症状或防止症状恶化或在最长的程度上保持当前状态。人的大脑是人体最敏感、最复杂的器官,受血脑屏障（BBB）保护。由于药物或纳米材料被大量抑制而无法到达病变部位，因此这仍然导致难以治愈AD。因此，药物递送系统的BBB穿越能力仍然是神经疗法发展中的重大挑战。幸运的是,由于纳米载体的迷人优势，纳米使能递送系统具有实现针对AD各种靶标的多功能诊断/治疗的潜力，包括简单的表面多功能化，具有大有效载荷的高表面体积比，和潜在的跨越血脑屏障的能力，使它们能够克服常规候选药物的局限性。这次审查,重点研究了多功能纳米材料在AD诊断和治疗中的BBB穿越能力，将提供一个有见地的愿景，有利于AD相关纳米材料的发展。
