Abstract：
The present review aimed to evaluate the apoptotic effect of tributyltin (TBT) exposure on mammalian tissues and cells in vivo. A search was conducted in specialized literature databases including Embase, Medline, Pubmed, Scholar Google, and Scopus for all manuscripts using the following keywords: \"tributyltin\", \"apoptosis\", \"mammals\", \"mammalian cells\', \"eukaryotic cells\", \'rodents\', \"rats\", \"mice\" and \"in vivo\" for all data published until September 2023. A total of 16 studies were included. The studies have demonstrated that TBT exposure induces apoptosis in cells from various mammalian organs or tissues in vivo. TBT is capable to increase apoptotic cells, to activate proapoptotic proteins such as calpain, caspases, bax and beclin-1 and to inhibit antiapoptotic protein bcl-2. Additionally, TBT alters the ratio of bcl-2/bax which favor apoptosis. Therefore, the activation of enzymes such as calpain induces apoptosis mediated by ERS and caspases through the intrinsic apoptosis pathway. This review has demonstrated that TBT exposure induces apoptosis in mammalian tissues and cells in vivo.
摘要：
本文旨在评估三丁基锡（TBT）暴露对体内哺乳动物组织和细胞的凋亡作用。在包括Embase在内的专业文献数据库中进行了搜索，Medline,Pubmed,学者谷歌，和Scopus使用以下关键字的所有手稿：“三丁基锡”，“凋亡”，“哺乳动物”，“哺乳动物细胞”，\"真核细胞\",\'啮齿动物\',\"老鼠\",直到2023年9月发布的所有数据的“小鼠”和“体内”。共纳入16项研究。研究表明，TBT暴露可诱导体内各种哺乳动物器官或组织的细胞凋亡。TBT能够增加凋亡细胞，激活促凋亡蛋白如钙蛋白酶，caspases,bax和beclin-1并抑制抗凋亡蛋白bcl-2。此外,TBT改变bcl-2/bax的比例，有利于细胞凋亡。因此,钙蛋白酶等酶的激活通过内在的凋亡途径诱导ERS和半胱天冬酶介导的凋亡。这篇综述已经证明TBT暴露在体内诱导哺乳动物组织和细胞凋亡。
