PDF(Pubmed)
Abstract：
UNASSIGNED: To determine the incidence of overt diabetes in pregnancy (ODIP) among women with 50-g GCT results ≥ 200 mg/dL and compare characteristics and pregnancy outcomes between women with and without gestational diabetes (GDM).
UNASSIGNED: A retrospective cohort study was conducted in 212 pregnant women whose 50-g GCT results ≥ 200 mg/dL. ODIP was diagnosed from 75-g OGTT if fasting plasma glucose ≥ 126 and/or 2-h plasma glucose ≥ 200 mg/dL. Various characteristics and pregnancy outcomes were compared between ODIP and those with and without GDM.
UNASSIGNED: Incidence of ODIP was 1.9% of all pregnant women and 23.6% of women with 50-g GCT ≥ 200 mg/dL. Women with ODIP and GDM were more likely to be overweight or obese than those without GDM (52%, 39.6%, and 18.2%, p < 0.001). Women with ODIP had significantly higher 50-g GCT results, lower gestational weight gain, and were less likely to deliver vaginally. Insulin therapy was significantly more common in women with ODIP compared to GDM (70.2% vs. 15.4%, p < 0.001). Rates of LGA, macrosomia, and other neonatal outcomes were comparable. BMI ≥ 25 kg/m2 and 50-g GCT ≥ 240 mg/dL independently increased the risk of any abnormal glucose tolerance [adjusted OR 3.22 (95% CI 1.55-6.70) and 2.28 (95% CI 1.14-4.58)] and ODIP [adjusted OR 9.43 (95% CI 2.15-41.38) and 6.36 (95% CI 2.85-14.18)], respectively.
UNASSIGNED: Incidence of ODIP was 23.6% of women with 50-g GCT ≥ 200 mg/dL. BMI ≥ 25 kg/m2 and 50-g GCT ≥ 240 mg/dL independently increased the risk of GDM and ODIP. Neonatal complications were comparable between ODIP and those with and without GDM.
UNASSIGNED: A retrospective cohort study was conducted in 212 pregnant women whose 50-g GCT results ≥ 200 mg/dL. ODIP was diagnosed from 75-g OGTT if fasting plasma glucose ≥ 126 and/or 2-h plasma glucose ≥ 200 mg/dL. Various characteristics and pregnancy outcomes were compared between ODIP and those with and without GDM.
UNASSIGNED: Incidence of ODIP was 1.9% of all pregnant women and 23.6% of women with 50-g GCT ≥ 200 mg/dL. Women with ODIP and GDM were more likely to be overweight or obese than those without GDM (52%, 39.6%, and 18.2%, p < 0.001). Women with ODIP had significantly higher 50-g GCT results, lower gestational weight gain, and were less likely to deliver vaginally. Insulin therapy was significantly more common in women with ODIP compared to GDM (70.2% vs. 15.4%, p < 0.001). Rates of LGA, macrosomia, and other neonatal outcomes were comparable. BMI ≥ 25 kg/m2 and 50-g GCT ≥ 240 mg/dL independently increased the risk of any abnormal glucose tolerance [adjusted OR 3.22 (95% CI 1.55-6.70) and 2.28 (95% CI 1.14-4.58)] and ODIP [adjusted OR 9.43 (95% CI 2.15-41.38) and 6.36 (95% CI 2.85-14.18)], respectively.
UNASSIGNED: Incidence of ODIP was 23.6% of women with 50-g GCT ≥ 200 mg/dL. BMI ≥ 25 kg/m2 and 50-g GCT ≥ 240 mg/dL independently increased the risk of GDM and ODIP. Neonatal complications were comparable between ODIP and those with and without GDM.
摘要：
■为了确定50-gGCT结果≥200mg/dL的女性中妊娠期显性糖尿病（ODIP）的发生率，并比较有和没有妊娠期糖尿病（GDM）的女性之间的特征和妊娠结局。
■对212名50克GCT结果≥200mg/dL的孕妇进行了一项回顾性队列研究。如果空腹血糖≥126和/或2小时血糖≥200mg/dL，则从75gOGTT诊断为ODIP。比较了ODIP与有和没有GDM的患者的各种特征和妊娠结局。
■ODIP的发生率为所有孕妇的1.9％，50-gGCT≥200mg/dL的妇女的发生率为23.6％。患有ODIP和GDM的女性比没有GDM的女性更可能超重或肥胖(52%,39.6%,和18.2%，p<0.001)。ODIP患者的50-gGCT结果明显更高，较低的妊娠期体重增加，阴道分娩的可能性较小。与GDM相比，ODIP女性中的胰岛素治疗更为普遍（70.2％vs.15.4%,p<0.001)。LGA的比率，巨大儿,和其他新生儿结局具有可比性.BMI≥25kg/m2和50gGCT≥240mg/dL独立地增加了任何糖耐量异常的风险[调整OR3.22（95％CI1.55-6.70）和2.28（95％CI1.14-4.58）]和ODIP[调整OR9.43（95％CI2.15-41.38）和6.36（95％CI2.85-14.18）]，分别。
■在50克GCT≥200mg/dL的女性中，ODIP的发生率为23.6%。BMI≥25kg/m2和50gGCT≥240mg/dL独立增加GDM和ODIP的风险。ODIP与有和没有GDM的新生儿并发症相当。
■对212名50克GCT结果≥200mg/dL的孕妇进行了一项回顾性队列研究。如果空腹血糖≥126和/或2小时血糖≥200mg/dL，则从75gOGTT诊断为ODIP。比较了ODIP与有和没有GDM的患者的各种特征和妊娠结局。
■ODIP的发生率为所有孕妇的1.9％，50-gGCT≥200mg/dL的妇女的发生率为23.6％。患有ODIP和GDM的女性比没有GDM的女性更可能超重或肥胖(52%,39.6%,和18.2%，p<0.001)。ODIP患者的50-gGCT结果明显更高，较低的妊娠期体重增加，阴道分娩的可能性较小。与GDM相比，ODIP女性中的胰岛素治疗更为普遍（70.2％vs.15.4%,p<0.001)。LGA的比率，巨大儿,和其他新生儿结局具有可比性.BMI≥25kg/m2和50gGCT≥240mg/dL独立地增加了任何糖耐量异常的风险[调整OR3.22（95％CI1.55-6.70）和2.28（95％CI1.14-4.58）]和ODIP[调整OR9.43（95％CI2.15-41.38）和6.36（95％CI2.85-14.18）]，分别。
■在50克GCT≥200mg/dL的女性中，ODIP的发生率为23.6%。BMI≥25kg/m2和50gGCT≥240mg/dL独立增加GDM和ODIP的风险。ODIP与有和没有GDM的新生儿并发症相当。
