PDF(Pubmed)
Abstract：
CRISPR-associated proteins and clustered regularly interspaced short palindromic repeats (CRISPR-Cas) technology has emerged as a groundbreaking advancement in animal and poultry nutrition to improve feed conversion efficiency, enhance disease resistance, and improve the nutritional quality of animal products. Despite significant advancements, there is a research gap in the systematic understanding and comprehensive use of the CRISPR-Cas method in animal and poultry nutrition. The purpose of this study is to elucidate the latest advancements in animal and poultry nutrition through CRISPR-Cas genome editing technology, focusing on gene manipulation in metabolism, immunity, and growth. Following preferred reporting items in meta-analysis and systematic reviews guidelines, we conducted a systematic search using several databases, including Scopus, PubMed, and Web of Science, until May 2024, and finally, we included a total of 108 articles in this study. This article explores the use of the CRISPR-Cas system in the advancement of feed additives like probiotics and enzymes, which could reduce the use of antibiotics in animal production. Furthermore, the article discusses ethical and regulatory issues related to gene editing in animal and poultry nutrition, including concerns about animal welfare, food safety, and environmental impacts. Overall, the CRISPR-Cas system holds substantial promise to overcome the challenges in modern animal agriculture. By enriching the nutritional quality of animal products, increasing disease resistance, and improving feed efficiency, it offers sustainable and cost-effective solutions that can revolutionize animal and poultry nutrition.
摘要：
CRISPR相关蛋白和成簇规则间隔短回文重复序列（CRISPR-Cas）技术已成为动物和家禽营养领域的突破性进展，以提高饲料转化效率。增强抗病性,提高畜产品的营养质量。尽管取得了重大进展，在对CRISPR-Cas方法在畜禽营养中的系统理解和综合运用方面存在研究空白。本研究的目的是通过CRISPR-Cas基因组编辑技术阐明动物和家禽营养的最新进展，专注于新陈代谢中的基因操纵，豁免权,和增长。遵循荟萃分析和系统评价指南中的首选报告项目，我们使用几个数据库进行了系统的搜索，包括Scopus,PubMed,和WebofScience,直到2024年5月，最后，本研究共纳入108篇文章.本文探讨了CRISPR-Cas系统在益生菌和酶等饲料添加剂发展中的应用。这可以减少抗生素在动物生产中的使用。此外，本文讨论了动物和家禽营养中与基因编辑相关的伦理和监管问题，包括对动物福利的担忧，食品安全,和环境影响。总的来说,CRISPR-Cas系统具有克服现代畜牧业挑战的巨大希望。通过丰富畜产品的营养品质,提高抗病性,提高饲料效率，它提供了可持续和具有成本效益的解决方案，可以彻底改变动物和家禽的营养。
