PDF(Pubmed)
Abstract：
Gastric cancer (GC) is the fourth most deadly cancer globally. The adducin 1 (ADD1) protein is involved in oncogenic signal transduction pathways in several types of cancer, and the rs4961 variant (c.1378 G>T, p.Gly460Trp) of the ADD1 gene is associated with salt-sensitive hypertension, renal cell cancer and breast cancer susceptibility; however, it has not been investigated in GC. The aim of the present study was to evaluate the association between the rs4961 variant and the development of GC and preneoplastic gastric lesions (PGLs) in a population from western Mexico. A total of 225 individuals who underwent an endoscopy were evaluated, of which 71 patients had histopathologically diagnosed GC and 53 patients had PGLs, with 101 patients used as controls. The rs4961 variant was genotyped by using PCR and DNA sequencing. The frequency of the mutated homozygous genotype (TT) of the rs4961 variant was <10% in the three evaluated groups, and the frequency of the minor allele (T) was <21% in the GC, PGL and control groups. Genotypic and allelic frequencies were similarly distributed in all of the studied groups (P>0.05). In summary, in the study population, the rs4961 variant was not associated with GC risk; however, its role in other populations and in other types of cancer is worthy of future research.
摘要：
胃癌（GC）是全球第四大致命癌症。在几种类型的癌症中，adducin1（ADD1）蛋白参与致癌信号转导途径，和rs4961变体(c.1378G>T，ADD1基因的p.Gly460Trp）与盐敏感性高血压有关，肾细胞癌和乳腺癌易感性；然而，它尚未在GC中进行调查。本研究的目的是评估rs4961变体与墨西哥西部人群中GC和肿瘤前胃病变（PGL）的发展之间的关系。总共对225名接受内窥镜检查的人进行了评估，其中71例患者有组织病理学诊断为GC，53例患者有PGLs，101名患者作为对照。通过使用PCR和DNA测序对rs4961变体进行基因分型。rs4961变体的突变纯合基因型（TT）的频率在三个评估组中<10％，在GC中次要等位基因（T）的频率<21％，PGL和对照组。基因型和等位基因频率在所有研究组中分布相似（P>0.05）。总之,在研究人群中，rs4961变体与GC风险无关；然而，它在其他人群和其他类型癌症中的作用值得未来研究。
