PDF(Pubmed)
Abstract：
Cryptococcus neoformans is a global invasive mycosis that is known to cause significant morbidity and mortality. It is commonly observed that individuals with compromised immune systems are more prone to developing cryptococcal meningitis. Although ocular involvement is rare, previous studies have indicated that ocular lesions precede symptomatic meningitis in only 27 % of patients with central nervous system involvement. Intraocular infections typically manifest as chorioretinopathy and vitreous inflammation, often leading to severe vision loss. In this case, we present the clinical details of a 57-year-old immunocompetent woman who visited the ophthalmology department of West China Hospital of Sichuan University with a progressive loss of vision in her right eye. After a thorough evaluation, she was diagnosed with fungal endophthalmitis, and subsequently initiated on appropriate induction anti-fungal therapy for cryptococcal meningoencephalitis. This case highlights the importance of early recognition and treatment, which can potentially improve the prognosis for patients.
摘要：
新生隐球菌是一种全球性的侵袭性真菌病，已知会导致大量的发病率和死亡率。通常观察到免疫系统受损的个体更容易发生隐球菌性脑膜炎。虽然眼部受累很少见，先前的研究表明，只有27％的中枢神经系统受累患者的眼部病变先于症状性脑膜炎。眼内感染通常表现为脉络膜视网膜病变和玻璃体炎症，常导致严重的视力丧失。在这种情况下,我们介绍了一名57岁免疫功能正常的女性的临床细节，她在四川大学华西医院眼科就诊，右眼视力逐渐丧失。经过全面评估，她被诊断为真菌性眼内炎,随后开始对隐球菌性脑膜脑炎进行适当的诱导抗真菌治疗。这个案例突出了早期识别和治疗的重要性,这可能会改善患者的预后。
