PDF(Pubmed)
Abstract：
UNASSIGNED: Evidence regarding the potential health effects of Life\'s Essential 8 (LE8) score among individuals with type 2 diabetes (T2D) is limited.
UNASSIGNED: The purpose of this study was to examine the associations of LE8 score with risk of cardiovascular disease (CVD) and mortality among individuals with T2D.
UNASSIGNED: We prospectively followed 19,915 Chinese participants with T2D at baseline or diagnosed during follow-up (Kailuan Study: 2006-2020), who were free of CVD at diagnosis of diabetes. Diet, lifestyle, and health conditions were repeatedly assessed every 2 years. The LE8 score (range 0-100), was calculated based on 8 components: diet quality, physical activity, smoking status, sleep health, body mass index, blood lipids, blood glucose, and blood pressure. We used time-varying cox models to model the associations.
UNASSIGNED: During a median follow-up of 11.5 years in participants with T2D, there were 3,295 incident CVD cases and 3,123 deaths. Higher LE8 score was associated with lower risk of CVD incidence and total mortality among participants with diabetes. The multivariate-adjusted HRs for the highest quintile of LE8 score compared with the lowest quintile were 0.56 (95% CI: 0.53-0.59) for CVD, 0.57 (95% CI: 0.53-0.62) for heart disease, 0.53 (95% CI: 0.49-0.57) for stroke, and 0.73 (95% CI: 0.69-0.78) for total mortality (all P trend <0.001). Furthermore, compared with participants with stable or decreased LE8 score after diabetes diagnosis, those with increased LE8 score had 17% to 42% lower risk of CVD, heart disease, stroke, and mortality.
UNASSIGNED: A higher LE8 score was associated with a substantially lower risk of CVD incidence and total mortality among adults with T2D.
UNASSIGNED: The purpose of this study was to examine the associations of LE8 score with risk of cardiovascular disease (CVD) and mortality among individuals with T2D.
UNASSIGNED: We prospectively followed 19,915 Chinese participants with T2D at baseline or diagnosed during follow-up (Kailuan Study: 2006-2020), who were free of CVD at diagnosis of diabetes. Diet, lifestyle, and health conditions were repeatedly assessed every 2 years. The LE8 score (range 0-100), was calculated based on 8 components: diet quality, physical activity, smoking status, sleep health, body mass index, blood lipids, blood glucose, and blood pressure. We used time-varying cox models to model the associations.
UNASSIGNED: During a median follow-up of 11.5 years in participants with T2D, there were 3,295 incident CVD cases and 3,123 deaths. Higher LE8 score was associated with lower risk of CVD incidence and total mortality among participants with diabetes. The multivariate-adjusted HRs for the highest quintile of LE8 score compared with the lowest quintile were 0.56 (95% CI: 0.53-0.59) for CVD, 0.57 (95% CI: 0.53-0.62) for heart disease, 0.53 (95% CI: 0.49-0.57) for stroke, and 0.73 (95% CI: 0.69-0.78) for total mortality (all P trend <0.001). Furthermore, compared with participants with stable or decreased LE8 score after diabetes diagnosis, those with increased LE8 score had 17% to 42% lower risk of CVD, heart disease, stroke, and mortality.
UNASSIGNED: A higher LE8 score was associated with a substantially lower risk of CVD incidence and total mortality among adults with T2D.
摘要：
■关于2型糖尿病（T2D）患者生命基础8（LE8）评分对健康的潜在影响的证据有限。
■本研究的目的是研究LE8评分与T2D患者心血管疾病（CVD）风险和死亡率的关系。
■我们前瞻性随访了19,915名患有T2D的中国参与者在基线时或在随访期间被诊断出来（开滦研究：2006-2020年），在诊断为糖尿病时没有心血管疾病的人。饮食,生活方式,健康状况每2年反复评估一次.LE8得分（范围0-100），是基于8个组成部分计算的：饮食质量，身体活动,吸烟状况,睡眠健康,身体质量指数,血脂,血糖，还有血压.我们使用时变cox模型对关联进行建模。
■在T2D参与者的中位随访11.5年期间，有3,295例心血管事件和3,123例死亡.在糖尿病参与者中，较高的LE8评分与较低的CVD发病率和总死亡率相关。LE8评分最高五分之一的多变量校正HR与CVD最低五分之一的多变量校正HR为0.56（95％CI：0.53-0.59），心脏病为0.57（95%CI：0.53-0.62），中风为0.53（95%CI：0.49-0.57），总死亡率为0.73（95%CI：0.69-0.78）（所有P趋势<0.001）。此外，与糖尿病诊断后LE8评分稳定或降低的参与者相比，LE8评分增加的患者患CVD的风险降低17%至42%,心脏病,中风,和死亡率。
较高的LE8评分与T2D成人中CVD发病率和总死亡率的显著降低相关。
■本研究的目的是研究LE8评分与T2D患者心血管疾病（CVD）风险和死亡率的关系。
■我们前瞻性随访了19,915名患有T2D的中国参与者在基线时或在随访期间被诊断出来（开滦研究：2006-2020年），在诊断为糖尿病时没有心血管疾病的人。饮食,生活方式,健康状况每2年反复评估一次.LE8得分（范围0-100），是基于8个组成部分计算的：饮食质量，身体活动,吸烟状况,睡眠健康,身体质量指数,血脂,血糖，还有血压.我们使用时变cox模型对关联进行建模。
■在T2D参与者的中位随访11.5年期间，有3,295例心血管事件和3,123例死亡.在糖尿病参与者中，较高的LE8评分与较低的CVD发病率和总死亡率相关。LE8评分最高五分之一的多变量校正HR与CVD最低五分之一的多变量校正HR为0.56（95％CI：0.53-0.59），心脏病为0.57（95%CI：0.53-0.62），中风为0.53（95%CI：0.49-0.57），总死亡率为0.73（95%CI：0.69-0.78）（所有P趋势<0.001）。此外，与糖尿病诊断后LE8评分稳定或降低的参与者相比，LE8评分增加的患者患CVD的风险降低17%至42%,心脏病,中风,和死亡率。
较高的LE8评分与T2D成人中CVD发病率和总死亡率的显著降低相关。
