UNASSIGNED: In our prospective cohort study, 1171 children aged 6-8 years were screened for sAGEs, BMI, retinal arteriolar diameters (CRAE) and pulse wave velocity (PWV), using standardized procedures. To determine CRF a 20 m shuttle run was performed. After four 4 years, all parameters were assessed in 675 children using the same protocols.
UNASSIGNED: Higher initial CRF levels were significantly associated with lower sAGEs (β [95 CI] -0.02 [-0.03 to -0.002] au, p = 0.022) levels at follow-up, although they showed a greater change from baseline to follow-up (β [95 CI] 0.02 [0.002 to 0.03] au, p = 0.027). Moreover, individuals with higher sAGEs at baseline showed narrower CRAE (β [95% CI] -5.42 [-8.76 to -2.08] μm, p = 0.001) at follow-up and showed a greater change in CRAE (β [95% CI] -3.99 [-7.03 to -0.96] μm, p = 0.010) from baseline to follow-up.
UNASSIGNED: Exercise and higher CRF may help mitigate the formation of AGEs during childhood, thereby reducing the risk for development of CV disease associated with AGEs-induced damage. Preventive strategies may need to target CRF early in life to achieve improvement of CV risk factors and may counteract the development of CV disease later in life.
■在我们的前瞻性队列研究中,对1171名6-8岁儿童进行了sAGEs筛查,BMI,视网膜小动脉直径(CRAE)和脉搏波速度(PWV),使用标准化程序。为了确定CRF,进行了20m穿梭运行。四年后,使用相同的方案对675名儿童的所有参数进行了评估.
■较高的初始CRF水平与较低的sAGEs(β[95CI]-0.02[-0.03至-0.002]au,p=0.022)随访时的水平,尽管它们从基线到随访显示出更大的变化(β[95CI]0.02[0.002至0.03]au,p=0.027)。此外,基线sAGEs较高的个体显示CRAE较窄(β[95%CI]-5.42[-8.76至-2.08]μm,p=0.001),在随访时显示CRAE有更大的变化(β[95%CI]-3.99[-7.03至-0.96]μm,p=0.010)从基线到随访。
■运动和更高的CRF可能有助于减轻儿童时期AGEs的形成,从而降低与AGEs诱导的损伤相关的CV疾病的发展风险。预防策略可能需要在生命早期针对CRF,以改善CV危险因素,并可能在以后的生活中抵消CV疾病的发展。