PDF(Pubmed)
Abstract：
UNASSIGNED: Skin-derived advanced glycation end products (sAGEs) have been associated with cardiovascular (CV) risk and mortality in adults. We hypothesize that cardiorespiratory fitness (CRF), body mass index (BMI) and vascular health are associated with development of sAGEs during childhood.
UNASSIGNED: In our prospective cohort study, 1171 children aged 6-8 years were screened for sAGEs, BMI, retinal arteriolar diameters (CRAE) and pulse wave velocity (PWV), using standardized procedures. To determine CRF a 20 m shuttle run was performed. After four 4 years, all parameters were assessed in 675 children using the same protocols.
UNASSIGNED: Higher initial CRF levels were significantly associated with lower sAGEs (β [95 CI] -0.02 [-0.03 to -0.002] au, p = 0.022) levels at follow-up, although they showed a greater change from baseline to follow-up (β [95 CI] 0.02 [0.002 to 0.03] au, p = 0.027). Moreover, individuals with higher sAGEs at baseline showed narrower CRAE (β [95% CI] -5.42 [-8.76 to -2.08] μm, p = 0.001) at follow-up and showed a greater change in CRAE (β [95% CI] -3.99 [-7.03 to -0.96] μm, p = 0.010) from baseline to follow-up.
UNASSIGNED: Exercise and higher CRF may help mitigate the formation of AGEs during childhood, thereby reducing the risk for development of CV disease associated with AGEs-induced damage. Preventive strategies may need to target CRF early in life to achieve improvement of CV risk factors and may counteract the development of CV disease later in life.
UNASSIGNED: In our prospective cohort study, 1171 children aged 6-8 years were screened for sAGEs, BMI, retinal arteriolar diameters (CRAE) and pulse wave velocity (PWV), using standardized procedures. To determine CRF a 20 m shuttle run was performed. After four 4 years, all parameters were assessed in 675 children using the same protocols.
UNASSIGNED: Higher initial CRF levels were significantly associated with lower sAGEs (β [95 CI] -0.02 [-0.03 to -0.002] au, p = 0.022) levels at follow-up, although they showed a greater change from baseline to follow-up (β [95 CI] 0.02 [0.002 to 0.03] au, p = 0.027). Moreover, individuals with higher sAGEs at baseline showed narrower CRAE (β [95% CI] -5.42 [-8.76 to -2.08] μm, p = 0.001) at follow-up and showed a greater change in CRAE (β [95% CI] -3.99 [-7.03 to -0.96] μm, p = 0.010) from baseline to follow-up.
UNASSIGNED: Exercise and higher CRF may help mitigate the formation of AGEs during childhood, thereby reducing the risk for development of CV disease associated with AGEs-induced damage. Preventive strategies may need to target CRF early in life to achieve improvement of CV risk factors and may counteract the development of CV disease later in life.
摘要：
■皮肤衍生的晚期糖基化终产物（sAGEs）与成人心血管（CV）风险和死亡率相关。我们假设心肺健康(CRF)，体重指数(BMI)和血管健康与儿童期sAGEs的发生有关.
■在我们的前瞻性队列研究中，对1171名6-8岁儿童进行了sAGEs筛查，BMI,视网膜小动脉直径（CRAE）和脉搏波速度（PWV），使用标准化程序。为了确定CRF,进行了20m穿梭运行。四年后，使用相同的方案对675名儿童的所有参数进行了评估.
■较高的初始CRF水平与较低的sAGEs（β[95CI]-0.02[-0.03至-0.002]au，p=0.022)随访时的水平，尽管它们从基线到随访显示出更大的变化(β[95CI]0.02[0.002至0.03]au，p=0.027)。此外，基线sAGEs较高的个体显示CRAE较窄(β[95%CI]-5.42[-8.76至-2.08]μm，p=0.001），在随访时显示CRAE有更大的变化（β[95%CI]-3.99[-7.03至-0.96]μm，p=0.010)从基线到随访。
■运动和更高的CRF可能有助于减轻儿童时期AGEs的形成，从而降低与AGEs诱导的损伤相关的CV疾病的发展风险。预防策略可能需要在生命早期针对CRF，以改善CV危险因素，并可能在以后的生活中抵消CV疾病的发展。
■在我们的前瞻性队列研究中，对1171名6-8岁儿童进行了sAGEs筛查，BMI,视网膜小动脉直径（CRAE）和脉搏波速度（PWV），使用标准化程序。为了确定CRF,进行了20m穿梭运行。四年后，使用相同的方案对675名儿童的所有参数进行了评估.
■较高的初始CRF水平与较低的sAGEs（β[95CI]-0.02[-0.03至-0.002]au，p=0.022)随访时的水平，尽管它们从基线到随访显示出更大的变化(β[95CI]0.02[0.002至0.03]au，p=0.027)。此外，基线sAGEs较高的个体显示CRAE较窄(β[95%CI]-5.42[-8.76至-2.08]μm，p=0.001），在随访时显示CRAE有更大的变化（β[95%CI]-3.99[-7.03至-0.96]μm，p=0.010)从基线到随访。
■运动和更高的CRF可能有助于减轻儿童时期AGEs的形成，从而降低与AGEs诱导的损伤相关的CV疾病的发展风险。预防策略可能需要在生命早期针对CRF，以改善CV危险因素，并可能在以后的生活中抵消CV疾病的发展。
