PDF(Pubmed)
Abstract：
UNASSIGNED: Aberrance in switching from default mode network (DMN) to fronto-parietal network (FPN) is proposed to underlie working memory deficits in subjects with substance use disorders, which can be studied using neuro-imaging techniques during cognitive tasks. The current study used EEG to investigate pre-stimulus microstates during the performance of Sternberg\'s working memory task in subjects with substance use disorders.
UNASSIGNED: 128-channel EEG was acquired and processed in ten age and gender-matched subjects, each with alcohol use disorder, opioid use disorder, and controls while they performed Sternberg\'s task. Behavioral parameters, pre-stimulus EEG microstate, and underlying sources were analyzed and compared between subjects with substance use disorders and controls.
UNASSIGNED: Both alcohol and opioid use disorder subjects had significantly lower accuracy (P < 0.01), while reaction times were significantly higher only in subjects of alcohol use disorder compared to controls (P < 0.01) and opioid use disorder (P < 0.01), reflecting working memory deficits of varying degrees in subjects with substance use disorders. Pre-stimulus EEG microstate revealed four topographic Maps 1-4: subjects of alcohol and opioid use disorder showing significantly lower mean duration of Map 3 (visual processing) and Map 2 (saliency and DMN switching), respectively, compared to controls (P < 0.05).
UNASSIGNED: Reduced mean durations in Map 3 and 2 in subjects of alcohol and opioid use disorder can underlie their poorer performance in Sternberg\'s task. Furthermore, cortical sources revealed higher activity in both groups of substance use disorders in the parahippocampal gyrus- a hub of DMN; superior and middle temporal gyri associated with impulsivity; and insula that maintains balance between executive reflective system and impulsive system. EEG microstates can be used to envisage neural underpinnings implicated for working memory deficits in subjects of alcohol and opioid use disorders, reflected by aberrant switching between neural networks and information processing mechanisms.
UNASSIGNED: 128-channel EEG was acquired and processed in ten age and gender-matched subjects, each with alcohol use disorder, opioid use disorder, and controls while they performed Sternberg\'s task. Behavioral parameters, pre-stimulus EEG microstate, and underlying sources were analyzed and compared between subjects with substance use disorders and controls.
UNASSIGNED: Both alcohol and opioid use disorder subjects had significantly lower accuracy (P < 0.01), while reaction times were significantly higher only in subjects of alcohol use disorder compared to controls (P < 0.01) and opioid use disorder (P < 0.01), reflecting working memory deficits of varying degrees in subjects with substance use disorders. Pre-stimulus EEG microstate revealed four topographic Maps 1-4: subjects of alcohol and opioid use disorder showing significantly lower mean duration of Map 3 (visual processing) and Map 2 (saliency and DMN switching), respectively, compared to controls (P < 0.05).
UNASSIGNED: Reduced mean durations in Map 3 and 2 in subjects of alcohol and opioid use disorder can underlie their poorer performance in Sternberg\'s task. Furthermore, cortical sources revealed higher activity in both groups of substance use disorders in the parahippocampal gyrus- a hub of DMN; superior and middle temporal gyri associated with impulsivity; and insula that maintains balance between executive reflective system and impulsive system. EEG microstates can be used to envisage neural underpinnings implicated for working memory deficits in subjects of alcohol and opioid use disorders, reflected by aberrant switching between neural networks and information processing mechanisms.
摘要：
■从默认模式网络（DMN）切换到额顶叶网络（FPN）的异常被提议为患有物质使用障碍的受试者的工作记忆缺陷的基础，可以在认知任务中使用神经成像技术进行研究。当前的研究使用EEG研究了在具有物质使用障碍的受试者中执行Sternberg的工作记忆任务期间的刺激前微观状态。
■在10名年龄和性别匹配的受试者中获取并处理128通道脑电图，每个人都有酒精使用障碍，阿片类药物使用障碍，和控件，而他们执行斯特恩伯格的任务。行为参数,预刺激脑电图微状态，和潜在来源进行了分析，并在有物质使用障碍的受试者和对照组之间进行了比较。
■酒精和阿片类药物使用障碍受试者的准确性均显着降低（P<0.01），而仅酒精使用障碍受试者的反应时间明显高于对照组（P<0.01）和阿片类药物使用障碍（P<0.01），反映物质使用障碍受试者不同程度的工作记忆缺陷。刺激前脑电图微状态显示四个地形图1-4：酒精和阿片类药物使用障碍的受试者显示出图3（视觉处理）和图2（显着性和DMN转换）的平均持续时间显着降低，分别,与对照组相比（P<0.05）。
■在酒精和阿片类药物使用障碍的受试者中，图3和图2的平均持续时间减少可能是他们在Sternberg任务中表现较差的原因。此外，皮质来源显示，海马旁回-DMN的枢纽，与冲动性相关的颞上和中回，以及维持执行反射系统和冲动系统之间平衡的脑岛，在两组物质使用障碍中均具有较高的活性。EEG微观状态可用于设想涉及酒精和阿片类药物使用障碍受试者的工作记忆缺陷的神经基础，反映在神经网络和信息处理机制之间的异常切换。
■在10名年龄和性别匹配的受试者中获取并处理128通道脑电图，每个人都有酒精使用障碍，阿片类药物使用障碍，和控件，而他们执行斯特恩伯格的任务。行为参数,预刺激脑电图微状态，和潜在来源进行了分析，并在有物质使用障碍的受试者和对照组之间进行了比较。
■酒精和阿片类药物使用障碍受试者的准确性均显着降低（P<0.01），而仅酒精使用障碍受试者的反应时间明显高于对照组（P<0.01）和阿片类药物使用障碍（P<0.01），反映物质使用障碍受试者不同程度的工作记忆缺陷。刺激前脑电图微状态显示四个地形图1-4：酒精和阿片类药物使用障碍的受试者显示出图3（视觉处理）和图2（显着性和DMN转换）的平均持续时间显着降低，分别,与对照组相比（P<0.05）。
■在酒精和阿片类药物使用障碍的受试者中，图3和图2的平均持续时间减少可能是他们在Sternberg任务中表现较差的原因。此外，皮质来源显示，海马旁回-DMN的枢纽，与冲动性相关的颞上和中回，以及维持执行反射系统和冲动系统之间平衡的脑岛，在两组物质使用障碍中均具有较高的活性。EEG微观状态可用于设想涉及酒精和阿片类药物使用障碍受试者的工作记忆缺陷的神经基础，反映在神经网络和信息处理机制之间的异常切换。
