PDF(Pubmed)
Abstract：
UNASSIGNED: Brain edema is a life-threatening complication that occurs after glioma surgery. There are no noninvasive and specific treatment methods for brain edema. Hydrogen is an anti-inflammatory and antioxidant gas that has demonstrated therapeutic and preventative effects on several diseases, particularly in the nervous system. This study aimed to determine the therapeutic effects of hydrogen administration on brain edema following glioma surgery and elucidate its mechanism.
UNASSIGNED: A single-center, randomized controlled clinical trial of hydrogen inhalation was conducted (China Clinical Trial Registry [ChiCTR-2300074362]). Participants in hydrogen (H) group that inhaled hydrogen experienced quicker alleviation of postoperative brain edema compared with participants in control (C) group that inhaled oxygen.
UNASSIGNED: The volume of brain edema before discharge was significantly lower in the H group (p < 0.05). Additionally, the regression rate of brain edema was higher in the H group than in the C group, which was statistically significant (p < 0.05). Furthermore, 3 days after surgery, the H group had longer total sleep duration, improved sleep efficiency, shorter sleep latency, and lower numerical rating scale (NRS) scores (p < 0.05).
UNASSIGNED: In conclusion, hydrogen/oxygen inhalation effectively reduced postoperative brain edema in glioma patients. Further research is necessary to understand the underlying mechanisms of hydrogen\'s therapeutic effects. Hydrogen is expected to become a new target for future adjuvant therapy for brain edema.
UNASSIGNED: A single-center, randomized controlled clinical trial of hydrogen inhalation was conducted (China Clinical Trial Registry [ChiCTR-2300074362]). Participants in hydrogen (H) group that inhaled hydrogen experienced quicker alleviation of postoperative brain edema compared with participants in control (C) group that inhaled oxygen.
UNASSIGNED: The volume of brain edema before discharge was significantly lower in the H group (p < 0.05). Additionally, the regression rate of brain edema was higher in the H group than in the C group, which was statistically significant (p < 0.05). Furthermore, 3 days after surgery, the H group had longer total sleep duration, improved sleep efficiency, shorter sleep latency, and lower numerical rating scale (NRS) scores (p < 0.05).
UNASSIGNED: In conclusion, hydrogen/oxygen inhalation effectively reduced postoperative brain edema in glioma patients. Further research is necessary to understand the underlying mechanisms of hydrogen\'s therapeutic effects. Hydrogen is expected to become a new target for future adjuvant therapy for brain edema.
摘要：
■脑水肿是神经胶质瘤手术后发生的危及生命的并发症。目前尚无针对脑水肿的非侵入性和特异性治疗方法。氢气是一种抗炎和抗氧化气体，对几种疾病具有治疗和预防作用，尤其是神经系统。本研究旨在确定氢气对胶质瘤手术后脑水肿的治疗作用，并阐明其机制。
■单中心，进行了氢气吸入的随机对照临床试验（中国临床试验注册中心[ChiCTR-2300074362]）。与吸入氧气的对照组（C）的参与者相比，吸入氢气的氢气（H）组的参与者术后脑水肿的缓解更快。
■出院前脑水肿体积明显低于H组（p<0.05）。此外,H组脑水肿消退率高于C组,有统计学意义(p<0.05)。此外，手术后3天,H组总睡眠时间较长,提高睡眠效率，更短的睡眠潜伏期，数值评定量表(NRS)得分较低(p<0.05)。
■总而言之，氢/氧吸入能有效减轻胶质瘤患者术后脑水肿。进一步的研究是必要的，以了解氢的治疗作用的潜在机制。氢气有望成为未来脑水肿辅助治疗的新靶点。
■单中心，进行了氢气吸入的随机对照临床试验（中国临床试验注册中心[ChiCTR-2300074362]）。与吸入氧气的对照组（C）的参与者相比，吸入氢气的氢气（H）组的参与者术后脑水肿的缓解更快。
■出院前脑水肿体积明显低于H组（p<0.05）。此外,H组脑水肿消退率高于C组,有统计学意义(p<0.05)。此外，手术后3天,H组总睡眠时间较长,提高睡眠效率，更短的睡眠潜伏期，数值评定量表(NRS)得分较低(p<0.05)。
■总而言之，氢/氧吸入能有效减轻胶质瘤患者术后脑水肿。进一步的研究是必要的，以了解氢的治疗作用的潜在机制。氢气有望成为未来脑水肿辅助治疗的新靶点。
