UNASSIGNED: A single-center, randomized controlled clinical trial of hydrogen inhalation was conducted (China Clinical Trial Registry [ChiCTR-2300074362]). Participants in hydrogen (H) group that inhaled hydrogen experienced quicker alleviation of postoperative brain edema compared with participants in control (C) group that inhaled oxygen.
UNASSIGNED: The volume of brain edema before discharge was significantly lower in the H group (p < 0.05). Additionally, the regression rate of brain edema was higher in the H group than in the C group, which was statistically significant (p < 0.05). Furthermore, 3 days after surgery, the H group had longer total sleep duration, improved sleep efficiency, shorter sleep latency, and lower numerical rating scale (NRS) scores (p < 0.05).
UNASSIGNED: In conclusion, hydrogen/oxygen inhalation effectively reduced postoperative brain edema in glioma patients. Further research is necessary to understand the underlying mechanisms of hydrogen\'s therapeutic effects. Hydrogen is expected to become a new target for future adjuvant therapy for brain edema.
■单中心,进行了氢气吸入的随机对照临床试验(中国临床试验注册中心[ChiCTR-2300074362])。与吸入氧气的对照组(C)的参与者相比,吸入氢气的氢气(H)组的参与者术后脑水肿的缓解更快。
■出院前脑水肿体积明显低于H组(p<0.05)。此外,H组脑水肿消退率高于C组,有统计学意义(p<0.05)。此外,手术后3天,H组总睡眠时间较长,提高睡眠效率,更短的睡眠潜伏期,数值评定量表(NRS)得分较低(p<0.05)。
■总而言之,氢/氧吸入能有效减轻胶质瘤患者术后脑水肿。进一步的研究是必要的,以了解氢的治疗作用的潜在机制。氢气有望成为未来脑水肿辅助治疗的新靶点。