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Abstract：
Several studies suggested the presence of non-motor symptoms in Essential Tremor (ET), including REM sleep behavioral disorder (RBD). RBD is an essential criterion for Prodromal Parkinson\'s Disease (PPD), suggesting a link between ET and PD. Our objective was to assess the prevalence and features of ET patients with RBD and PDD. RBD was diagnosed by questionnaire screening, followed by polysomnography. PPD risk factors and prodromic markers were assessed with a structured protocol. Patients were characterized regarding tremor features. ET patients with RBD (ET-RBD) and PPD (ET-PPD) were compared to patients without RBD (ET-nonRBD) and without PPD (ET-nonPPD), respectively. ET-RBD patients were also compared with a group of isolated RBD (iRBD) regarding PPD features. We assessed a total of 64 ET patients. Five (8.3 %) and 4 (6.3 %) had criteria for RBD and PPD, respectively. ET-RBD patients did not differ from ET-nonRBD except for a higher prevalence of PPD. There were no significant differences between ET-RBD and iRBD (n = 12) groups. ET-PPD had a higher prevalence of positive DaT-Scans and RBD compared to ET-nonPPD. Three ET-RBD patients had PPD and 3 ET-PPD had RBD. Both RBD and PPD are more frequent in ET patients than in general aged population but not related with specific tremor features. ET-RBD patients did not differ significantly from iRBD patients, a group prone to develop PD. These data suggest a link between ET and PD and are in accordance with studies showing an increase incidence of lewy-body pathology and PD in ET populations.
摘要：
几项研究表明，原发性震颤（ET）存在非运动症状，包括REM睡眠行为障碍（RBD）。RBD是前驱帕金森病（PPD）的基本标准，暗示ET和PD之间有联系.我们的目的是评估患有RBD和PDD的ET患者的患病率和特征。RBD是通过问卷调查诊断的，其次是多导睡眠图。用结构化方案评估PPD危险因素和前驱标志物。患者的特征在于震颤特征。将有RBD（ET-RBD）和PPD（ET-PPD）的ET患者与无RBD（ET-nonRBD）和无PPD（ET-nonPPD）的患者进行比较，分别。还比较了ET-RBD患者与一组孤立的RBD（iRBD）的PPD特征。我们总共评估了64例ET患者。5人(8.3%)和4人(6.3%)有RBD和PPD的标准，分别。ET-RBD患者与ET-nonRBD患者没有差异，只是PPD的患病率较高。ET-RBD组和iRBD组(n=12)之间无显著差异。与ET-nonPPD相比，ET-PPD的DaT-Scans和RBD阳性患病率更高。3例ET-RBD患者有PPD，3例ET-PPD患者有RBD。ET患者的RBD和PPD均比一般老年人群更常见，但与特定的震颤特征无关。ET-RBD患者与iRBD患者无显著差异,容易发展为PD的群体。这些数据表明ET和PD之间存在联系，并且与显示ET人群中lewy体病理学和PD发生率增加的研究一致。
