Abstract：
Efferocytosis refers to the process by which phagocytes remove apoptotic cells and related apoptotic products. It is essential for the growth and development of the body, the repair of damaged or inflamed tissues, and the balance of the immune system. Damaged efferocytosis will cause a variety of chronic inflammation and immune system diseases. Many studies show that efferocytosis is a process mediated by mitochondria. Mitochondrial metabolism, mitochondrial dynamics, and communication between mitochondria and other organelles can all affect phagocytes\' clearance of apoptotic cells. Therefore, targeting mitochondria to modulate phagocyte efferocytosis is an anticipated strategy to prevent and treat chronic inflammatory diseases and autoimmune diseases. In this review, we introduced the mechanism of efferocytosis and the pivoted role of mitochondria in efferocytosis. In addition, we focused on the therapeutic implication of drugs targeting mitochondria in diseases related to efferocytosis dysfunction.
摘要：
细胞作用是指吞噬细胞去除凋亡细胞和相关凋亡产物的过程。它对身体的生长发育至关重要，修复受损或发炎的组织，以及免疫系统的平衡.受损的红细胞增多会引起多种慢性炎症和免疫系统疾病。许多研究表明，细胞凋亡是由线粒体介导的过程。线粒体代谢，线粒体动力学，线粒体和其他细胞器之间的通讯都可以影响吞噬细胞对凋亡细胞的清除。因此,靶向线粒体调节吞噬细胞的作用是预防和治疗慢性炎症性疾病和自身免疫性疾病的预期策略。在这次审查中,我们介绍了细胞增生的机制和线粒体在细胞增生中的作用。此外,我们重点研究了针对线粒体的药物在与有效细胞功能失调相关疾病中的治疗意义.
