Abstract：
Glycosylation, a crucial posttranslational modification, plays a significant role in numerous physiological and pathological processes. Lectin microarrays, which leverage the high specificity of lectins for sugar binding, are ideally suited for profiling the glycan spectra of diverse and complex biological samples. In this review, we explore the evolution of lectin detection technologies, as well as the applications and challenges of lectin microarrays in analyzing the glycome profiles of various clinical samples, including serum, saliva, tissues, sperm, and urine. This review not only emphasizes significant advancements in the high-throughput analysis of polysaccharides but also provides insight into the potential of lectin microarrays for diagnosing and managing diseases such as tumors, autoimmune diseases, and chronic inflammation. We aim to provide a clear, concise, and comprehensive overview of the use of lectin microarrays in clinical settings, thereby assisting researchers in conducting clinical studies in glycobiology.
摘要：
糖基化,一个关键的翻译后修饰，在许多生理和病理过程中起着重要作用。凝集素微阵列，利用凝集素对糖结合的高特异性，非常适合分析不同和复杂的生物样品的聚糖光谱。在这次审查中,我们探索凝集素检测技术的演变，以及凝集素微阵列在分析各种临床样本的糖图谱中的应用和挑战，包括血清,唾液,组织，精子,还有尿液.这篇综述不仅强调了多糖高通量分析的重大进展，而且还提供了对凝集素微阵列用于诊断和管理肿瘤等疾病的潜力的见解。自身免疫性疾病，慢性炎症。我们的目标是提供一个明确的，简洁,以及在临床环境中使用凝集素微阵列的全面概述，从而帮助研究人员进行糖生物学的临床研究。
