Abstract：
Biofilm formation by bacteria poses a significant challenge across diverse industries, displaying resilience against conventional antimicrobial agents. Nanoparticles emerge as a promising alternative for addressing biofilm-related issues. This review aims to assess the efficacy of metal and metal oxide nanoparticles in inhibiting or disrupting biofilm formation by various bacterial species. It delineates trends, identifies gaps, and outlines avenues for future research, emphasizing best practices and optimal nanoparticles for biofilm prevention and eradication. Additionally, it underscores the potential of nanoparticles as substitutes for traditional antibiotics in healthcare and combating antibiotic resistance. A systematic literature search, encompassing Web of Science, PubMed, and Google Scholar from 2015 to 2023, yielded 48 publications meeting the review criteria. These studies employed diverse methods to explore the antibacterial activity of nanoparticles against biofilmforming bacteria strains. The implications of this study are profound, offering prospects for novel antimicrobial agents targeting biofilm-forming bacteria, often resistant to conventional antibiotics. In conclusion, nanoparticles present a promising frontier in countering biofilm-forming bacteria. This review delivers a structured analysis of current research, providing insights into the potential and challenges of nanoparticle utilization against biofilm-related challenges. While nanoparticles exhibit inherent antimicrobial properties with applications spanning healthcare, agriculture, and industries, the review acknowledges limitations such as the narrow scope of tested nanoparticles and the imperative need for extensive research on long-term toxicity and environmental impacts.
摘要：
细菌生物膜的形成对不同行业构成了重大挑战，表现出对常规抗菌剂的抵抗力。纳米颗粒作为解决生物膜相关问题的有希望的替代方案出现。这篇综述旨在评估金属和金属氧化物纳米颗粒在抑制或破坏各种细菌物种形成生物膜方面的功效。它描绘了趋势，识别差距，并概述了未来研究的途径，强调预防和根除生物膜的最佳实践和最佳纳米颗粒。此外,它强调了纳米颗粒在医疗保健和对抗抗生素耐药性方面作为传统抗生素替代品的潜力。系统的文献检索,包括WebofScience，PubMed,和GoogleScholar从2015年到2023年，产生了48种符合审查标准的出版物。这些研究采用了多种方法来探索纳米颗粒对生物膜形成细菌菌株的抗菌活性。这项研究的意义是深远的，为靶向生物膜形成细菌的新型抗菌剂提供了前景，通常对常规抗生素有抗药性。总之,纳米粒子在对抗生物膜形成细菌方面提出了有希望的前沿。这篇综述对当前的研究进行了结构化分析，提供对纳米颗粒利用对抗生物膜相关挑战的潜力和挑战的见解。虽然纳米颗粒表现出固有的抗微生物特性，应用范围涵盖医疗保健领域，农业,和工业，该评论承认局限性，例如测试的纳米颗粒范围狭窄，以及迫切需要对长期毒性和环境影响进行广泛研究。
