PDF(Pubmed)
Abstract：
The investigation of aberrations in lipid metabolism within tumor has become a burgeoning field of study that has garnered significant attention in recent years. Lipids can serve as a potent source of highly energetic fuel to support the rapid growth of neoplasia, in where the ER-mitochondrial membrane domains (ERMMDs) provide an interactive network for facilitating communication between ER and mitochondria as well as their intermembrane space and adjunctive proteins. In this review, we discuss fatty acids (FAs) anabolic and catabolic metabolism, as well as how CPT1A-VDAC-ACSL clusters on ERMMDs participate in FAs transport, with a major focus on ERMMDs mediated collaborative loop of FAO, Ca2+ transmission in TCA cycle and OXPHOS process. Here, we present a comprehensive perspective on the regulation of aberrant lipid metabolism through ERMMDs conducted tumor physiology might be a promising and potential target for tumor starvation therapy.
摘要：
近年来，对肿瘤内脂质代谢异常的研究已成为一个新兴的研究领域，引起了广泛的关注。脂质可以作为高能燃料的有效来源，以支持肿瘤的快速生长。其中ER-线粒体膜结构域（ERMMDs）提供了促进ER和线粒体之间的交流以及它们的膜间空间和辅助蛋白的相互作用网络。在这次审查中,我们讨论脂肪酸（FAs）合成代谢和分解代谢，以及ERMMD上的CPT1A-VDAC-ACSL集群如何参与FA传输，主要关注ERMMD介导的粮农组织协作循环，Ca2+在TCA轮回和OXPHOS进程中的传输。这里,我们提出了通过ERMMD进行的肿瘤生理学调节异常脂质代谢的全面观点，这可能是肿瘤饥饿治疗的有希望和潜在的靶标。
