Abstract：
BACKGROUND: A clinical trial was conducted to measure the effectiveness of a combined wavelength of 660 nm and 808 nm Low-Level Laser Therapy (LLLT) in reducing postoperative pain in partially and totally edentulous patients who underwent dental implant surgery.
METHODS: The study included 20 blinded individuals divided in a randomized split-mouth fashion; the experimental group in one hemiarch and the control group in the other hemiarch. The experimental group received a total of 22.5 Joules (J) of LLLT divided into 5 points per implant immediately after surgery. The control group received a placebo treatment. At 24 h, 72 h, and 7 days, a blinded surveyor administered a pain questionnaire using a Numerical Rating Scale (NRS) combined with a Verbal Rating Scale (VRS) to assess pain onset after surgery, duration of the first pain episode, and pain evolution. Group data were analyzed with an ANOVA test for repeated measures and a paired t-test at defined time intervals.
RESULTS: The experimental group showed a significant decrease in postoperative pain at 24 h and at 72 h for fully edentulous patients. There was a non-significant difference in the duration of the first pain episode. The mean pain levels decreased over time for both the experimental and control treatments, but only statistically significantly for the experimental group in the 24-72 h and 24 h to 7 days intervals. The same was true for the control group when comparing 24 and 72 h and between 24 h and 1 week. The time range between 72 h and 1 week showed no statistically significant differences.
CONCLUSIONS: Within the limitations of this study, a single dose of 22.5 J LLLT per implant helps to decrease postoperative pain in dental implant surgery at 24 h for partially edentulous patients and at 24 and 72 h for fully edentulous patients.
METHODS: The study included 20 blinded individuals divided in a randomized split-mouth fashion; the experimental group in one hemiarch and the control group in the other hemiarch. The experimental group received a total of 22.5 Joules (J) of LLLT divided into 5 points per implant immediately after surgery. The control group received a placebo treatment. At 24 h, 72 h, and 7 days, a blinded surveyor administered a pain questionnaire using a Numerical Rating Scale (NRS) combined with a Verbal Rating Scale (VRS) to assess pain onset after surgery, duration of the first pain episode, and pain evolution. Group data were analyzed with an ANOVA test for repeated measures and a paired t-test at defined time intervals.
RESULTS: The experimental group showed a significant decrease in postoperative pain at 24 h and at 72 h for fully edentulous patients. There was a non-significant difference in the duration of the first pain episode. The mean pain levels decreased over time for both the experimental and control treatments, but only statistically significantly for the experimental group in the 24-72 h and 24 h to 7 days intervals. The same was true for the control group when comparing 24 and 72 h and between 24 h and 1 week. The time range between 72 h and 1 week showed no statistically significant differences.
CONCLUSIONS: Within the limitations of this study, a single dose of 22.5 J LLLT per implant helps to decrease postoperative pain in dental implant surgery at 24 h for partially edentulous patients and at 24 and 72 h for fully edentulous patients.
摘要：
背景：进行了一项临床试验，以测量660nm和808nm组合波长的低水平激光治疗（LLLT）在减轻部分和完全无牙颌患者术后疼痛中的有效性。
方法：该研究包括20个盲症个体，以随机分口方式进行分组；实验组为一个半叶，对照组为另一个半叶。实验组在手术后立即接受总共22.5焦耳（J）的LLLT，每个植入物分为5点。对照组接受安慰剂治疗。24小时后,72小时,7天,盲法测量师使用数字评定量表（NRS）结合言语评定量表（VRS）进行疼痛问卷，以评估手术后的疼痛发作，第一次疼痛发作的持续时间，和痛苦进化。用ANOVA检验对重复测量进行分析，并在定义的时间间隔进行配对t检验。
结果：对于完全无牙颌患者，实验组在24小时和72小时的术后疼痛显着减轻。第一次疼痛发作的持续时间没有显着差异。实验和对照治疗的平均疼痛水平随着时间的推移而下降，但仅在24-72小时和24小时至7天间隔的实验组具有统计学意义。当比较24和72小时以及24小时和1周之间时,对照组也是如此。72小时至1周之间的时间范围没有统计学上的显着差异。
结论：在本研究的局限性内，对于部分缺牙患者,每个种植体单剂量22.5JLLLT有助于减少牙种植体手术24小时和完全缺牙患者24小时和72小时的术后疼痛.
方法：该研究包括20个盲症个体，以随机分口方式进行分组；实验组为一个半叶，对照组为另一个半叶。实验组在手术后立即接受总共22.5焦耳（J）的LLLT，每个植入物分为5点。对照组接受安慰剂治疗。24小时后,72小时,7天,盲法测量师使用数字评定量表（NRS）结合言语评定量表（VRS）进行疼痛问卷，以评估手术后的疼痛发作，第一次疼痛发作的持续时间，和痛苦进化。用ANOVA检验对重复测量进行分析，并在定义的时间间隔进行配对t检验。
结果：对于完全无牙颌患者，实验组在24小时和72小时的术后疼痛显着减轻。第一次疼痛发作的持续时间没有显着差异。实验和对照治疗的平均疼痛水平随着时间的推移而下降，但仅在24-72小时和24小时至7天间隔的实验组具有统计学意义。当比较24和72小时以及24小时和1周之间时,对照组也是如此。72小时至1周之间的时间范围没有统计学上的显着差异。
结论：在本研究的局限性内，对于部分缺牙患者,每个种植体单剂量22.5JLLLT有助于减少牙种植体手术24小时和完全缺牙患者24小时和72小时的术后疼痛.
