Abstract：
BACKGROUND: COVID-19 infection shows variant symptoms apart from respiratory symptoms, including the orofacial pain. We aim to research the morbidity, characteristics and potential risk factors of orofacial pain associated with COVID-19 pandemic in China from December 2022 to early 2023.
METHODS: A cross-sectional survey was conducted in Fujian Province, China. The demographic and characteristic data of the subjects were collected and analysed.
RESULTS: A total of 1526 subjects responded to the survey. The morbidity of orofacial pain increased significantly before and after COVID-19 infection. (42.26% vs. 46.52%, P < .001) A total of 217 (14.22%) subjects with orofacial pain before COVID-19 infection reported the phenomenon of \"COVID-19 infection with orofacial pain\" (CIOP). Univariate and multivariate logistic regression showed that male (OR = 1.761, P < .001) and other symptoms of COVID-19 (OR = 1.494, P < .001) may be the risk factors for the aggravation of CIOP, while the time of first infection (OR = 0.580, P = .004) and preference for drinking tea or coffee (OR = 0.610, P = .003) may be the protective factors for the aggravation of CIOP. While, the subjects who did not concern about the spread of COVID-19 in oral treatment (OR = 0.639, P = .001), female (OR = 0.749, P = .03), education level (OR = 1.687, P < .001) and income level (OR = 1.796, P < .001), higher PSS-10 score (OR = 1.076, P < .001), and more drugs taken for infection (OR = 1.330, P < .001) were more willing to seek medical treatment.
CONCLUSIONS: The morbidity of orofacial pain appears to have increased significantly due to the COVID-19 epidemic; a number of factors can influence the CIOP including gender, infection period, and beverage preference\' psychological factors, gender, education and income level can also influence the intent to seek a dentist.
METHODS: A cross-sectional survey was conducted in Fujian Province, China. The demographic and characteristic data of the subjects were collected and analysed.
RESULTS: A total of 1526 subjects responded to the survey. The morbidity of orofacial pain increased significantly before and after COVID-19 infection. (42.26% vs. 46.52%, P < .001) A total of 217 (14.22%) subjects with orofacial pain before COVID-19 infection reported the phenomenon of \"COVID-19 infection with orofacial pain\" (CIOP). Univariate and multivariate logistic regression showed that male (OR = 1.761, P < .001) and other symptoms of COVID-19 (OR = 1.494, P < .001) may be the risk factors for the aggravation of CIOP, while the time of first infection (OR = 0.580, P = .004) and preference for drinking tea or coffee (OR = 0.610, P = .003) may be the protective factors for the aggravation of CIOP. While, the subjects who did not concern about the spread of COVID-19 in oral treatment (OR = 0.639, P = .001), female (OR = 0.749, P = .03), education level (OR = 1.687, P < .001) and income level (OR = 1.796, P < .001), higher PSS-10 score (OR = 1.076, P < .001), and more drugs taken for infection (OR = 1.330, P < .001) were more willing to seek medical treatment.
CONCLUSIONS: The morbidity of orofacial pain appears to have increased significantly due to the COVID-19 epidemic; a number of factors can influence the CIOP including gender, infection period, and beverage preference\' psychological factors, gender, education and income level can also influence the intent to seek a dentist.
摘要：
背景：除呼吸道症状外，COVID-19感染还表现出其他症状，包括口面部疼痛.我们的目标是研究发病率，2022年12月至2023年初中国与COVID-19大流行相关的口面部疼痛的特征和潜在危险因素。
方法：在福建省进行了横断面调查，中国。收集并分析受试者的人口统计学和特征数据。
结果：共有1526名受试者回答了调查。COVID-19感染前后口面部疼痛的发病率显着增加。（42.26%与46.52%,P<.001)共有217例(14.22%)在感染COVID-19前出现口面部疼痛的受试者报告了“COVID-19感染伴口面部疼痛”(CIOP)的现象。单因素和多因素logistic回归分析显示,男性(OR=1.761,P<.001)和其他COVID-19症状(OR=1.494,P<.001)可能是CIOP加重的危险因素,而首次感染时间（OR=0.580，P=.004）和喝茶或咖啡的偏好（OR=0.610，P=.003）可能是CIOP加重的保护因素。同时,不关注COVID-19在口服治疗中传播的受试者（OR=0.639，P=.001），女性（OR=0.749，P=0.03），教育水平（OR=1.687，P<.001）和收入水平（OR=1.796，P<.001），PSS-10评分较高(OR=1.076，P<.001)，且因感染而服用的药物较多(OR=1.330,P<.001),患者更愿意求医。
结论：由于COVID-19的流行，口面部疼痛的发病率似乎显着增加；许多因素可以影响CIOP，包括性别，感染期间,和饮料偏好的心理因素，性别,教育和收入水平也会影响寻求牙医的意图。
方法：在福建省进行了横断面调查，中国。收集并分析受试者的人口统计学和特征数据。
结果：共有1526名受试者回答了调查。COVID-19感染前后口面部疼痛的发病率显着增加。（42.26%与46.52%,P<.001)共有217例(14.22%)在感染COVID-19前出现口面部疼痛的受试者报告了“COVID-19感染伴口面部疼痛”(CIOP)的现象。单因素和多因素logistic回归分析显示,男性(OR=1.761,P<.001)和其他COVID-19症状(OR=1.494,P<.001)可能是CIOP加重的危险因素,而首次感染时间（OR=0.580，P=.004）和喝茶或咖啡的偏好（OR=0.610，P=.003）可能是CIOP加重的保护因素。同时,不关注COVID-19在口服治疗中传播的受试者（OR=0.639，P=.001），女性（OR=0.749，P=0.03），教育水平（OR=1.687，P<.001）和收入水平（OR=1.796，P<.001），PSS-10评分较高(OR=1.076，P<.001)，且因感染而服用的药物较多(OR=1.330,P<.001),患者更愿意求医。
结论：由于COVID-19的流行，口面部疼痛的发病率似乎显着增加；许多因素可以影响CIOP，包括性别，感染期间,和饮料偏好的心理因素，性别,教育和收入水平也会影响寻求牙医的意图。
