Abstract：
OBJECTIVE: Gastroesophageal reflux disease (GERD) and temporomandibular joint disorder (TMD) are relatively common conditions with a potential causal relationship. This study aims to investigate the possible causal relationship between GERD and TMD through bidirectional Mendelian randomization analysis.
METHODS: Using data from large GWAS databases, we conducted bidirectional Mendelian randomization analyses to investigate the potential causal link between GERD and TMD. Instrumental variables were selected from the IEU platform, comprising 129,080 GERD cases and 473,524 controls from the UK Biobank. TMD data from the FinnGen project included 6,314 cases and 222,498 controls.
RESULTS: The forward MR analysis suggested that GERD may increase the risk of TMD (OR = 1.47, 95% CI: 1.20-1.81, P = 2e-4). The Weighted Median method also yielded significant results (OR = 1.53, 95% CI: 1.14-2.04, P = 4.1e-3). However, the reverse MR analysis did not reveal a significant association between TMD and GERD (OR = 1.02, 95% CI: 0.98-1.05, P = .33).
CONCLUSIONS: This study, employing MR analysis, provides initial evidence supporting a potential causal relationship between GERD and TMD. The findings contribute to a better understanding of the relationship between these two conditions and offer insights for future clinical investigations.
CONCLUSIONS: The findings of this study hold potential clinical significance in guiding early management strategies for GERD, reducing the incidence of TMD, and optimizing healthcare resource allocation, thereby improving patient quality of life. Further clinical studies are warranted to validate these findings and explore underlying mechanisms.
METHODS: Using data from large GWAS databases, we conducted bidirectional Mendelian randomization analyses to investigate the potential causal link between GERD and TMD. Instrumental variables were selected from the IEU platform, comprising 129,080 GERD cases and 473,524 controls from the UK Biobank. TMD data from the FinnGen project included 6,314 cases and 222,498 controls.
RESULTS: The forward MR analysis suggested that GERD may increase the risk of TMD (OR = 1.47, 95% CI: 1.20-1.81, P = 2e-4). The Weighted Median method also yielded significant results (OR = 1.53, 95% CI: 1.14-2.04, P = 4.1e-3). However, the reverse MR analysis did not reveal a significant association between TMD and GERD (OR = 1.02, 95% CI: 0.98-1.05, P = .33).
CONCLUSIONS: This study, employing MR analysis, provides initial evidence supporting a potential causal relationship between GERD and TMD. The findings contribute to a better understanding of the relationship between these two conditions and offer insights for future clinical investigations.
CONCLUSIONS: The findings of this study hold potential clinical significance in guiding early management strategies for GERD, reducing the incidence of TMD, and optimizing healthcare resource allocation, thereby improving patient quality of life. Further clinical studies are warranted to validate these findings and explore underlying mechanisms.
摘要：
目的：胃食管反流病（GERD）和颞下颌关节紊乱（TMD）是相对常见的疾病，具有潜在的因果关系。本研究旨在通过双向孟德尔随机化分析探讨GERD与TMD之间可能的因果关系。
方法：使用来自大型GWAS数据库的数据，我们进行了双向孟德尔随机化分析,以研究GERD和TMD之间的潜在因果关系.从IEU平台选择工具变量，包括来自英国生物库的129,080例GERD病例和473,524例对照。FinnGen项目的TMD数据包括6,314例病例和222,498例对照。
结果：前向MR分析提示GERD可能增加TMD的风险（OR=1.47，95％CI：1.20-1.81，P=2e-4）。加权中值方法也产生了显著的结果(OR=1.53,95%CI:1.14-2.04,P=4.1e-3)。然而,反向MR分析未显示TMD与GERD之间存在显著关联(OR=1.02,95%CI:0.98-1.05,P=.33).
结论：这项研究，采用MR分析，提供了支持GERD和TMD之间潜在因果关系的初步证据。这些发现有助于更好地理解这两种情况之间的关系，并为未来的临床研究提供见解。
结论：本研究结果对指导GERD的早期治疗策略具有潜在的临床意义。减少TMD的发病率，优化医疗资源配置，从而提高患者的生活质量。需要进一步的临床研究来验证这些发现并探索潜在的机制。
方法：使用来自大型GWAS数据库的数据，我们进行了双向孟德尔随机化分析,以研究GERD和TMD之间的潜在因果关系.从IEU平台选择工具变量，包括来自英国生物库的129,080例GERD病例和473,524例对照。FinnGen项目的TMD数据包括6,314例病例和222,498例对照。
结果：前向MR分析提示GERD可能增加TMD的风险（OR=1.47，95％CI：1.20-1.81，P=2e-4）。加权中值方法也产生了显著的结果(OR=1.53,95%CI:1.14-2.04,P=4.1e-3)。然而,反向MR分析未显示TMD与GERD之间存在显著关联(OR=1.02,95%CI:0.98-1.05,P=.33).
结论：这项研究，采用MR分析，提供了支持GERD和TMD之间潜在因果关系的初步证据。这些发现有助于更好地理解这两种情况之间的关系，并为未来的临床研究提供见解。
结论：本研究结果对指导GERD的早期治疗策略具有潜在的临床意义。减少TMD的发病率，优化医疗资源配置，从而提高患者的生活质量。需要进一步的临床研究来验证这些发现并探索潜在的机制。
