Abstract：
BACKGROUND: Stomach, small intestine, and colon have distinct patterns of contraction related to their function to mix and propel enteric contents. In this study, we aim to measure gut myoelectric activity in the perioperative course using external patches in an animal model.
METHODS: Four external patches were placed on the abdominal skin of female Yucatan pigs to record gastrointestinal myoelectric signals for 3 to 5 d. Pigs subsequently underwent anesthesia and placement of internal electrodes on stomach, small intestine, and colon. Signals were collected by a wireless transmitter. Frequencies associated with peristalsis were analyzed for both systems for 6 d postoperatively.
RESULTS: In awake pigs, we found frequency peaks in several ranges, from 4 to 6.5 cycles per minute (CPM), 8 to 11 CPM, and 14 to 18 CPM, which were comparable between subjects and concordant between internal and external recordings. The possible effect of anesthesia during the 1 or 2 h before surgical manipulation was observed as a 59% (±36%) decrease in overall myoelectric activity compared to the immediate time before anesthesia. The myoelectrical activity recovered quickly postoperatively. Comparing the absolute postsurgery activity levels to the baseline for each pig revealed higher overall activity after surgery by a factor of 1.69 ± 0.3.
CONCLUSIONS: External patch measurements correlated with internal electrode recordings. Anesthesia and surgery impacted gastrointestinal myoelectric activity. Recordings demonstrated a rebound phenomenon in myoelectric activity in the postoperative period. The ability to monitor gastrointestinal tract myoelectric activity noninvasively over multiple days could be a useful tool in diagnosing gastrointestinal motility disorders.
METHODS: Four external patches were placed on the abdominal skin of female Yucatan pigs to record gastrointestinal myoelectric signals for 3 to 5 d. Pigs subsequently underwent anesthesia and placement of internal electrodes on stomach, small intestine, and colon. Signals were collected by a wireless transmitter. Frequencies associated with peristalsis were analyzed for both systems for 6 d postoperatively.
RESULTS: In awake pigs, we found frequency peaks in several ranges, from 4 to 6.5 cycles per minute (CPM), 8 to 11 CPM, and 14 to 18 CPM, which were comparable between subjects and concordant between internal and external recordings. The possible effect of anesthesia during the 1 or 2 h before surgical manipulation was observed as a 59% (±36%) decrease in overall myoelectric activity compared to the immediate time before anesthesia. The myoelectrical activity recovered quickly postoperatively. Comparing the absolute postsurgery activity levels to the baseline for each pig revealed higher overall activity after surgery by a factor of 1.69 ± 0.3.
CONCLUSIONS: External patch measurements correlated with internal electrode recordings. Anesthesia and surgery impacted gastrointestinal myoelectric activity. Recordings demonstrated a rebound phenomenon in myoelectric activity in the postoperative period. The ability to monitor gastrointestinal tract myoelectric activity noninvasively over multiple days could be a useful tool in diagnosing gastrointestinal motility disorders.
摘要：
背景：胃，小肠,和结肠有不同的收缩模式，与它们混合和推进肠内容物的功能有关。在这项研究中,我们的目标是在动物模型中使用外部贴片测量围手术期过程中的肠道肌电活动。
方法：在雌性尤卡坦猪腹部皮肤上放置4个外贴，记录3~5d的胃肠肌电信号。猪随后接受麻醉并在胃上放置内电极，小肠,和结肠。信号由无线发射器收集。术后6d分析了两个系统的蠕动相关频率。
结果：在清醒的猪中，我们在几个范围内发现了频率峰值，从4到6.5循环/分钟（CPM），8到11CPM，和14到18CPM，受试者之间具有可比性，内部和外部记录之间具有一致性。观察到手术操作前1或2小时麻醉的可能效果，与麻醉前的即时时间相比，整体肌电活动降低了59％（±36％）。术后肌电活动迅速恢复。将每只猪的绝对手术后活性水平与基线进行比较，显示手术后的总活性更高1.69±0.3倍。
结论：外部贴片测量与内部电极记录相关。麻醉和手术影响胃肠肌电活动。记录显示术后肌电活动有反弹现象。在多天内非侵入性监测胃肠道肌电活动的能力可能是诊断胃肠运动性疾病的有用工具。
方法：在雌性尤卡坦猪腹部皮肤上放置4个外贴，记录3~5d的胃肠肌电信号。猪随后接受麻醉并在胃上放置内电极，小肠,和结肠。信号由无线发射器收集。术后6d分析了两个系统的蠕动相关频率。
结果：在清醒的猪中，我们在几个范围内发现了频率峰值，从4到6.5循环/分钟（CPM），8到11CPM，和14到18CPM，受试者之间具有可比性，内部和外部记录之间具有一致性。观察到手术操作前1或2小时麻醉的可能效果，与麻醉前的即时时间相比，整体肌电活动降低了59％（±36％）。术后肌电活动迅速恢复。将每只猪的绝对手术后活性水平与基线进行比较，显示手术后的总活性更高1.69±0.3倍。
结论：外部贴片测量与内部电极记录相关。麻醉和手术影响胃肠肌电活动。记录显示术后肌电活动有反弹现象。在多天内非侵入性监测胃肠道肌电活动的能力可能是诊断胃肠运动性疾病的有用工具。
