PDF(Pubmed)
Abstract：
Cardiometabolic risk factors increase the chance of developing cardiovascular disease (CVD) and type 2 diabetes. Most CVD risk factors are influenced by total and regional obesity. A higher risk of developing CVD may be linked to vitamin D deficiency, which is more prevalent in the older population. With the goal of evaluating the association between vitamin D and cardiometabolic risk factors and total and regional obesity in older adults, this research included 25 (OH) vitamin D3 concentrations and biochemical markers associated with cardiometabolic diseases, as well as total and regional adiposity, which was measured by DXA. A total of 1991 older participants in the PoCOsteo study were included. Overall, 38.5% of participants had vitamin D deficiency. After adjusting for confounders, the results of multiple linear and logistic regression suggested an inverse association between vitamin D and body mass index (P = 0.04), waist circumference (P = 0.001), total fat (P = 0.02), android fat (P = 0.001), visceral fat (P < 0.001), subcutaneous fat (P = 0.01), trunk fat (P = 0.006), arm fat (P = 0.03), high systolic blood pressure (P = 0.004), high total cholesterol (P < 0.001), high LDL-cholesterol (P < 0.001), high serum triglycerides (P = 0.001), and high fasting glucose (P < 0.001). Additionally, higher vitamin D concentrations decreased the risk of dyslipidemia by 2%. Our results showed a significant association between serum vitamin D and a number of cardiometabolic risk factors, including total and regional obesity.
摘要：
心血管代谢危险因素会增加患心血管疾病（CVD）和2型糖尿病的机会。大多数CVD危险因素受整体和区域肥胖的影响。患CVD的风险较高可能与维生素D缺乏有关，这在老年人群中更为普遍。为了评估维生素D和心脏代谢危险因素与老年人总体和区域肥胖之间的关系，这项研究包括25（OH）维生素D3浓度和与心脏代谢疾病相关的生化标志物，以及总体和区域肥胖，由DXA测量。共有1991年的老年人参加了PoCOsteo研究。总的来说,38.5%的参与者有维生素D缺乏。在调整了混杂因素后，多元线性和逻辑回归的结果表明维生素D与体重指数呈负相关（P=0.04），腰围（P=0.001），总脂肪（P=0.02），Android脂肪（P=0.001），内脏脂肪（P<0.001），皮下脂肪（P=0.01），躯干脂肪（P=0.006），手臂脂肪（P=0.03），高收缩压（P=0.004），高总胆固醇（P<0.001），高LDL-胆固醇（P<0.001），高血清甘油三酯（P=0.001），空腹血糖偏高(P<0.001)。此外,较高的维生素D浓度将血脂异常的风险降低2%.我们的结果显示，血清维生素D与许多心脏代谢危险因素之间存在显着关联，包括整体和区域肥胖。
