Abstract：
Ovarian cancer, an aggressive malignancy of the female reproductive tract, is frequently linked to an elevated risk of thrombotic events. This association is manifested by a pronounced rise in platelet counts and activation levels. Current research firmly supports the pivotal role of platelets in the oncogenic processes of ovarian cancer, influencing tumor cell proliferation and metastasis. Platelets influence these processes through direct interactions with tumor cells or by secreting cytokines and growth factors that enhance tumor growth, angiogenesis, and metastasis. This review aims to thoroughly dissect the interactions between platelets and ovarian cancer cells, emphasizing their combined role in tumor progression and associated thrombotic events. Additionally, it summarizes therapeutic strategies targeting platelet-cancer interface which show significant promise. Such approaches could not only be effective in managing the primary ovarian tumor but also play a pivotal role in preventing metastasis and attenuating thrombotic complications associated with ovarian cancer.
摘要：
卵巢癌,女性生殖道的侵袭性恶性肿瘤，通常与血栓形成事件的风险升高有关。这种关联表现为血小板计数和活化水平的显著升高。目前的研究坚定地支持血小板在卵巢癌的致癌过程中的关键作用，影响肿瘤细胞增殖和转移。血小板通过与肿瘤细胞的直接相互作用或通过分泌促进肿瘤生长的细胞因子和生长因子来影响这些过程。血管生成,和转移。本文旨在彻底剖析血小板与卵巢癌细胞之间的相互作用。强调它们在肿瘤进展和相关血栓形成事件中的联合作用。此外,它总结了针对血小板-癌症界面的治疗策略，这些策略显示出重大前景。这种方法不仅可以有效地管理原发性卵巢肿瘤，而且在预防转移和减轻与卵巢癌相关的血栓并发症中起关键作用。
