METHODS: Patients with diagnosis of parotid ACC treated at our institution were included in this retrospective study. Patient factors were examined, and patients were grouped by extent of resection and tumor grade.
RESULTS: 58 patients, including 32 low-grade, 7 intermediate-grade, and 14 high-grade were included. Patients with low-grade tumors were more likely to undergo lesser extent of parotidectomy and less likely to undergo neck dissection. Two patients with low grade tumors developed recurrence, one local and one regional. Recurrence rate did not differ with resection extent in low-grade tumors. High tumor grade was found to be associated with disease progression. There was no association with adjuvant treatment and outcomes. Across all tumor grades advanced AJCC stage was found to be associated with disease progression.
CONCLUSIONS: In ACC patients with low-grade tumors and lower disease stage who undergo lesser extent of surgical resection oncologic outcomes were favorable. Patients with high-grade tumors carry a high risk of recurrence, despite aggressive treatment. AJCC stage and histopathologic grade may predict outcomes and guide treatment.
方法:本回顾性研究纳入我院诊断为腮腺ACC的患者。检查患者因素,根据切除程度和肿瘤分级对患者进行分组.
结果:58例患者,包括32个低等级,7个中级,包括14名高年级学生。患有低度肿瘤的患者更有可能接受较小程度的腮腺切除术,而不太可能接受颈部清扫术。两名低度肿瘤患者复发,一个地方和一个地区。低级别肿瘤的复发率与切除程度没有差异。发现高肿瘤分级与疾病进展相关。与辅助治疗和结果无关。在所有肿瘤等级中,发现晚期AJCC阶段与疾病进展相关。
结论:在接受手术切除程度较低的低级别肿瘤和疾病分期较低的ACC患者中,肿瘤预后良好。高级别肿瘤患者具有很高的复发风险,尽管积极的治疗。AJCC分期和组织病理学分级可以预测结果并指导治疗。