Abstract：
OBJECTIVE: Practical considerations precluding health-related quality of life (HRQOL) monitoring in population and clinical research have spawned development of improved items for more brief surveys of frequently measured HRQOL outcomes. The aim of this study was to validate the use of the Quality of Life General (QGEN-8), a shorter 8-item alternative to the longer 36-item short form (SF)-36 Health Survey for measuring the same eight HRQOL domains across groups of adults with varying severity of acute respiratory symptoms, such as cough and sore throat.
METHODS: National Opinion Research Center (NORC) representative probability (N = 1,648) and supplemental opt-in (N = 5,915) U.S. adult samples were surveyed cross-sectionally online in 2020. Parallel analyses compared QGEN-8 and SF-36 estimates of group means for each of eight matching profile domains and summary physical and mental scores across groups differing in severity of acute symptoms and chronic respiratory conditions using analysis of covariance (ANCOVAs) controlling for socio-demographics and presence of chronic respiratory conditions.
RESULTS: In support of discriminant validity, ANCOVA estimates of QGEN-8 means with SF-36 estimates revealed the same patterns of declining HRQOL with the presence and increasing severity of symptoms and chronic condition severity.
CONCLUSIONS: QGEN-8® shows satisfactory validity and warrants further testing in cross-sectional and longitudinal population and clinical survey research as a more practical method for estimating group differences in SF-36 profile and summary component HRQOL scores.
Upper respiratory tract infections (URTI) with symptoms such as cough and sore throat are highly prevalent and negatively impact on health-related quality of life (HRQOL). Existing instruments that comprehensively measure HRQOL are lengthy, potentially increasing respondent burden and restricting their use in clinical studies and research. The aim of this study was to evaluate whether eight newly constructed survey items, the QGEN-8®, measure the same HRQOL outcomes as the 36-item SF-36 Health Survey well enough to serve as a more practical alternative for purposes of detecting the physical and mental HRQOL effects on differing severity of acute URTI symptoms, specifically cough and sore throat. The results showed that the QGEN-8® was psychometrically sound and able to differentiate between different levels of URTI symptoms, even in cases where respondents had chronic respiratory conditions. This indicates that the briefer QGEN-8® with 75% shorter response time is able to provide HRQOL measurements comparable to those derived from lengthier instruments thereby lending itself more readily to use in clinical studies and research of URTI symptoms, such as cough and sore throat.
METHODS: National Opinion Research Center (NORC) representative probability (N = 1,648) and supplemental opt-in (N = 5,915) U.S. adult samples were surveyed cross-sectionally online in 2020. Parallel analyses compared QGEN-8 and SF-36 estimates of group means for each of eight matching profile domains and summary physical and mental scores across groups differing in severity of acute symptoms and chronic respiratory conditions using analysis of covariance (ANCOVAs) controlling for socio-demographics and presence of chronic respiratory conditions.
RESULTS: In support of discriminant validity, ANCOVA estimates of QGEN-8 means with SF-36 estimates revealed the same patterns of declining HRQOL with the presence and increasing severity of symptoms and chronic condition severity.
CONCLUSIONS: QGEN-8® shows satisfactory validity and warrants further testing in cross-sectional and longitudinal population and clinical survey research as a more practical method for estimating group differences in SF-36 profile and summary component HRQOL scores.
Upper respiratory tract infections (URTI) with symptoms such as cough and sore throat are highly prevalent and negatively impact on health-related quality of life (HRQOL). Existing instruments that comprehensively measure HRQOL are lengthy, potentially increasing respondent burden and restricting their use in clinical studies and research. The aim of this study was to evaluate whether eight newly constructed survey items, the QGEN-8®, measure the same HRQOL outcomes as the 36-item SF-36 Health Survey well enough to serve as a more practical alternative for purposes of detecting the physical and mental HRQOL effects on differing severity of acute URTI symptoms, specifically cough and sore throat. The results showed that the QGEN-8® was psychometrically sound and able to differentiate between different levels of URTI symptoms, even in cases where respondents had chronic respiratory conditions. This indicates that the briefer QGEN-8® with 75% shorter response time is able to provide HRQOL measurements comparable to those derived from lengthier instruments thereby lending itself more readily to use in clinical studies and research of URTI symptoms, such as cough and sore throat.
摘要：
目的：在人群和临床研究中排除健康相关生活质量（HRQOL）监测的实际考虑已经催生了改进项目的发展，用于对频繁测量的HRQOL结果进行更简短的调查。这项研究的目的是验证生活质量综述(QGEN-8)的使用，较短的8项替代较长的36项简表（SF）-36健康调查，用于测量急性呼吸道症状严重程度不同的成年人群体中相同的8个HRQOL域，如咳嗽和喉咙痛。
方法：国家舆论研究中心（NORC）代表概率（N=1,648）和补充选择（N=5,915）美国成年人样本在2020年进行了横断面调查。平行分析比较了QGEN-8和SF-36对8个匹配概况域中每个域的组均值的估计，并使用协方差分析（ANCOVA）控制了急性症状和慢性呼吸系统疾病的严重程度不同的组的身体和心理评分。社会人口统计学和慢性呼吸系统疾病的存在。
结果：支持判别效度，QGEN-8均值的ANCOVA估计值与SF-36估计值揭示了随着症状和慢性疾病严重程度的存在和增加，HRQOL下降的相同模式。
结论：QGEN-8®显示出令人满意的有效性，并值得在横断面和纵向人群以及临床调查研究中进行进一步测试，作为估计SF-36概况和汇总成分HRQOL评分的群体差异的更实用方法。
伴有咳嗽和喉咙痛等症状的上呼吸道感染(URTI)非常普遍，并对健康相关生活质量(HRQOL)产生负面影响。全面衡量HRQOL的现有工具很长，可能会增加应答者的负担，并限制其在临床研究和研究中的使用。这项研究的目的是评估八个新建的调查项目，QGEN-8®，测量与36项SF-36健康调查相同的HRQOL结果，足以作为更实用的替代方案，用于检测身体和精神HRQOL对不同严重程度的急性URTI症状的影响，特别是咳嗽和喉咙痛。结果显示，QGEN-8®在心理上是健全的，能够区分不同程度的URTI症状，即使在受访者患有慢性呼吸系统疾病的情况下。这表明响应时间更短的QGEN-8®能够提供与从更长的仪器获得的HRQOL测量结果相当的HRQOL测量结果，从而使其更容易用于临床研究和URTI症状研究。如咳嗽和喉咙痛。
方法：国家舆论研究中心（NORC）代表概率（N=1,648）和补充选择（N=5,915）美国成年人样本在2020年进行了横断面调查。平行分析比较了QGEN-8和SF-36对8个匹配概况域中每个域的组均值的估计，并使用协方差分析（ANCOVA）控制了急性症状和慢性呼吸系统疾病的严重程度不同的组的身体和心理评分。社会人口统计学和慢性呼吸系统疾病的存在。
结果：支持判别效度，QGEN-8均值的ANCOVA估计值与SF-36估计值揭示了随着症状和慢性疾病严重程度的存在和增加，HRQOL下降的相同模式。
结论：QGEN-8®显示出令人满意的有效性，并值得在横断面和纵向人群以及临床调查研究中进行进一步测试，作为估计SF-36概况和汇总成分HRQOL评分的群体差异的更实用方法。
伴有咳嗽和喉咙痛等症状的上呼吸道感染(URTI)非常普遍，并对健康相关生活质量(HRQOL)产生负面影响。全面衡量HRQOL的现有工具很长，可能会增加应答者的负担，并限制其在临床研究和研究中的使用。这项研究的目的是评估八个新建的调查项目，QGEN-8®，测量与36项SF-36健康调查相同的HRQOL结果，足以作为更实用的替代方案，用于检测身体和精神HRQOL对不同严重程度的急性URTI症状的影响，特别是咳嗽和喉咙痛。结果显示，QGEN-8®在心理上是健全的，能够区分不同程度的URTI症状，即使在受访者患有慢性呼吸系统疾病的情况下。这表明响应时间更短的QGEN-8®能够提供与从更长的仪器获得的HRQOL测量结果相当的HRQOL测量结果，从而使其更容易用于临床研究和URTI症状研究。如咳嗽和喉咙痛。
