Abstract：
Dysphagia is common in motor neurone disease (MND) and associated with negative health and psychosocial outcomes. Although largely considered a motor disease, a growing body of evidence suggests that MND can also affect the sensory system. As intact sensation is vital for safe swallowing, and sensory changes can influence the clinical management of dysphagia in people living with MND, this review evaluated and summarised the current evidence for sensory changes related to swallowing in MND. Of 3,481 articles originally identified, 29 met the inclusion criteria. Of these, 20 studies reported sensory changes, which included laryngeal sensation, taste, gag reflex, cough reflex, tongue sensation, smell, palatal and pharyngeal sensation, silent aspiration, and undefined sensation of the swallowing mechanism. Sensory changes were either described as decreased (n = 16) or heightened (n = 4). In the remaining nine studies, sensory function was reported as unaffected. The presence of changes to sensory function related to swallowing in MND remains inconclusive, although an increasing number of studies report sensory changes in some sensory domains. Future research is needed to evaluate the prevalence of sensory changes in MND and how such changes may influence dysphagia and its management.
摘要：
吞咽困难在运动神经元疾病（MND）中很常见，并与负面健康和社会心理结果有关。虽然在很大程度上被认为是一种运动疾病，越来越多的证据表明MND也会影响感觉系统。因为完整的感觉对于安全吞咽至关重要，感觉变化会影响MND患者吞咽困难的临床治疗，这篇综述评估并总结了目前MND吞咽相关感觉变化的证据。在最初确定的3481篇文章中，29符合纳入标准。其中,20项研究报告了感官变化，其中包括喉觉，味道,呕吐反射,咳嗽反射,舌头的感觉，气味,腭和咽感，无声的渴望，和不确定的吞咽机制的感觉。感官变化被描述为减少(n=16)或增加(n=4)。在剩下的九项研究中，据报道感觉功能未受影响.MND中与吞咽相关的感觉功能变化的存在尚不确定，尽管越来越多的研究报告了某些感官领域的感官变化。需要进一步的研究来评估MND的感觉变化的患病率以及这种变化如何影响吞咽困难及其管理。
