METHODS: We examined the attributes of serum tumor markers, imaging characteristics, and histological findings in individuals diagnosed with IP, both with and without concurrent lung cancer.
RESULTS: 106 patients diagnosed with IP were included in the study, comprising 36 individuals with concurrent lung cancer and 70 patients solely diagnosed with IP. Serum concentrations of CEA and CA12-5 were notably elevated in IP patients with lung cancer, compared to those with IP alone. Logistic regression analyses revealed that, in comparison to IP patients within the first quartile of CEA levels, the relative risk of developing lung cancer associated with IP escalated by 4.0-fold, 3.1-fold, 11.0-fold, and 13.3-fold in the second, third, fourth, and fifth quartiles, respectively. Upon controlling for gender and age, statistical significance in risk was observed solely for the fourth and fifth quartiles. Receiver operating characteristic (ROC) curve analysis conducted in patients diagnosed with ILD-CA identified a CEA cutoff point of 6.9 ng/mL, demonstrating sensitivities of 61.1% and specificities of 78.5%. The area under the curve was calculated as 0.7(95% CI: 0.63-0.81).
CONCLUSIONS: The serum levels of CEA were notably elevated in IP patients with concurrent lung cancer in contrast to those who were just suffering from IP. The heightened serum CEA levels correlate with an escalated risk of cancer occurrence among IP patients, suggesting that serum CEA levels could potentially serve as an indicative marker for the presence of cancer in IP patients.
方法:我们检查了血清肿瘤标志物的属性,成像特性,以及诊断为IP的个体的组织学发现,有和没有并发肺癌。
结果:106名诊断为IP的患者被纳入研究,包括36例并发肺癌患者和70例仅诊断为IP的患者。IP肺癌患者血清CEA和CA12-5浓度显著升高,与那些只有IP的人相比。Logistic回归分析显示,与CEA水平第一四分位数内的IP患者相比,与IP相关的发展为肺癌的相对风险增加了4.0倍,3.1折,11.0倍,第二次是13.3倍,第三,第四,和第五个四分位数,分别。在控制性别和年龄后,仅在第四和第五四分位数观察到风险的统计学显著性.在诊断为ILD-CA的患者中进行的受试者工作特征(ROC)曲线分析确定了6.9ng/mL的CEA截止点,敏感性为61.1%,特异性为78.5%。曲线下面积计算为0.7(95%CI:0.63-0.81)。
结论:与刚刚患有IP的患者相比,IP并发肺癌患者的血清CEA水平明显升高。血清CEA水平升高与IP患者癌症发生风险升高相关,提示血清CEA水平可能作为IP患者存在癌症的指示性标志物。