Abstract：
Around 7% of the male population in the world are entangle with considerable situation which is known as male infertility. Photobiomodulation therapy (PBMT) is the application of low-level laser radiation, that recently used to increase or promote the various cell functions including, proliferation, differentiation, ATP production, gene expressions, regulation of reactive oxygen spices (ROS), and also boost the tissue healing and reduction of inflammation. This systematic review\'s main idea is a comprehensive appraisal of the literatures on subjects of PBMT consequences in four light ranges wavelength (blue, green, red, near-infrared (NIR)) on sperm cell characteristics, in vitro and in vivo. In this study, PubMed, Google Scholar, and Scopus databases were used for abstracts and full-text scientific papers published from 2003-2023 that reported the application of PBM on sperm cells. Criteria\'s for inclusion and exclusion to review were applied. Finally, the studies that matched with our goals were included, classified, and reported in detail. Also, searched studies were subdivided into the effects of four ranges of light irradiation, including the blue light range (400-500 nm), green light range (500-600 nm), red light range (600-780 nm), and NIR light range (780-3000 nm) of laser irradiation on human or animal sperm cells, in situations of in vitro or in vivo. Searches with our keywords results in 137 papers. After primary analysis, some articles were excluded because they were review articles or incomplete and unrelated studies. Finally, we use the 63 articles for this systematic review. Our category tables were based on the light range of irradiation, source of sperm cells (human or animal cells) and being in vitro or in vivo. Six% of publications reported the effects of blue, 10% green, 53% red and 31% NIR, light on sperm cell. In general, most of these studies showed that PBMT exerted a positive effect on the sperm cell motility. The various effects of PBMT in different wavelength ranges, as mentioned in this review, provide more insights for its potential applications in improving sperm characteristics. PBMT as a treatment method has significant effectiveness for treatment of different medical problems. Due to the lack of reporting data in this field, there is a need for future studies to assessment the biochemical and molecular effects of PBMT on sperm cells for the possible application of this treatment to the human sperm cells before the ART process.
摘要：
世界上约有7％的男性人口与相当大的情况纠缠在一起，这被称为男性不育。光生物调节疗法（PBMT）是低水平激光辐射的应用，最近用于增加或促进各种细胞功能，包括，扩散,分化,ATP生产，基因表达，调节活性氧香料（ROS），并促进组织愈合和减少炎症。本系统综述的主要思想是对PBMT在四个光范围波长(蓝色，绿色,红色,近红外（NIR）对精子细胞特性的影响，在体外和体内。在这项研究中,PubMed,谷歌学者，和Scopus数据库用于2003-2023年发表的摘要和全文科学论文，这些论文报道了PBM在精子细胞上的应用。适用纳入和排除审查的标准。最后,包括了与我们的目标相匹配的研究，机密，并详细报道。此外，搜索的研究被细分为四个范围的光照射的影响，包括蓝光范围（400-500nm），绿光范围（500-600nm），红光范围（600-780nm），以及对人类或动物精子细胞进行激光照射的NIR光范围（780-3000nm），在体外或体内的情况下。搜索我们的关键词会产生137篇论文。经过初步分析,一些文章被排除在外,因为它们是综述文章或不完整且不相关的研究.最后,我们使用63篇文章进行本系统综述。我们的分类表是基于照射的光线范围，精子细胞（人或动物细胞）的来源，并且在体外或体内。6%的出版物报道了蓝色的影响，10%绿色,53%红色和31%近红外，光在精子细胞上。总的来说,大多数研究表明PBMT对精子细胞运动有积极作用。PBMT在不同波长范围内的各种效应,正如这篇评论中提到的，为其在改善精子特性方面的潜在应用提供更多见解。PBMT作为一种治疗方法，对于治疗不同的医学问题具有显著的有效性。由于该领域缺乏报告数据，需要未来的研究来评估PBMT对精子细胞的生化和分子效应,以便在ART过程之前将这种治疗应用于人类精子细胞.
