朊病毒样结构域介导的 ARID1A 相分离促进尤文氏肉瘤的致癌潜力。
Mesh : Humans Sarcoma, Ewing / genetics metabolism pathology Transcription Factors / metabolism genetics DNA-Binding Proteins / metabolism genetics Cell Line, Tumor RNA-Binding Protein EWS / metabolism genetics Chromatin Assembly and Disassembly Gene Expression Regulation, Neoplastic Cell Proliferation Oncogene Proteins, Fusion / metabolism genetics Proto-Oncogene Protein c-fli-1 / metabolism genetics Chromatin / metabolism Carcinogenesis / genetics Animals Mice Protein Domains Bone Neoplasms / genetics metabolism pathology Phase Separation
来 源:
DOI:10.1038/s41467-024-51050-0
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