Abstract：
Dysregulation of the epigenomic landscape of tumor cells has been implicated in the pathogenesis of pancreatic cancer. However, these alterations are not only restricted to neoplastic cells. The behavior of other cell populations in the tumor stroma such as cancer-associated fibroblasts, immune cells, and others are mostly regulated by epigenetic pathways. Here, we present an overview of the main cellular and acellular components of the pancreatic cancer tumor microenvironment and discuss how the epigenetic mechanisms operate at different levels in the stroma to establish a differential gene expression to regulate distinct cellular phenotypes contributing to pancreatic tumorigenesis.
摘要：
肿瘤细胞表观基因组景观的失调与胰腺癌的发病机理有关。然而,这些改变不仅限于肿瘤细胞。其他细胞群体在肿瘤基质中的行为，如癌症相关的成纤维细胞，免疫细胞，和其他主要是由表观遗传途径调节。这里,我们概述了胰腺癌肿瘤微环境的主要细胞和无细胞成分，并讨论了表观遗传机制如何在基质中不同水平起作用，以建立差异基因表达来调节导致胰腺肿瘤发生的不同细胞表型。
