Abstract：
OBJECTIVE: Acute pulmonary embolism (PE) is a potentially life-threatening condition characterized by the sudden blockage of the pulmonary arteries. Although the MAGGIC risk score has emerged as a valuable tool in predicting outcomes in patients with chronic heart failure, it has also been demonstrated and identified as a prognostic model in various cardiac diseases other than heart failure. In this study, we aimed to investigate the relationship between MAGGIC score and adverse outcomes in patients with PE.
METHODS: A total of 302 consecutive patients diagnosed with acute PE were retrospectively included in the present study. For each patient, the MAGGIC score was calculated. The study population was divided into two groups according to the median value of MAGGIC score.
RESULTS: Patients with high MAGGIC score had a significantly higher proportion of elderly and female individuals, lower BMI, higher presence of CAD, DM, AFib, HF, HT, CKD, COPD, and ACEI/ARB and NOAC usage. Logistic regression analyses was carried out using univariate and multivariate analysis to predict the in-hospital and 30-day mortality predictors in the included PE patients. For in-hospital mortality, diastolic blood pressure, heart rate, RV dilatation, and the MAGGIC score (HR: 1.166, 95 % CI 1.077-1.263, p < 0.001) and for short-term mortality, sPESI and the MAGGIC score (HR: 1.925, 95 % CI 1.243-2.983, p:0.003) were found to be independent predictors for adverse outcomes in patients with acute PE.
CONCLUSIONS: Our study demonstrates that the MAGGIC score can be applied as a valuable prognostic tool for acute pulmonary embolism.
METHODS: A total of 302 consecutive patients diagnosed with acute PE were retrospectively included in the present study. For each patient, the MAGGIC score was calculated. The study population was divided into two groups according to the median value of MAGGIC score.
RESULTS: Patients with high MAGGIC score had a significantly higher proportion of elderly and female individuals, lower BMI, higher presence of CAD, DM, AFib, HF, HT, CKD, COPD, and ACEI/ARB and NOAC usage. Logistic regression analyses was carried out using univariate and multivariate analysis to predict the in-hospital and 30-day mortality predictors in the included PE patients. For in-hospital mortality, diastolic blood pressure, heart rate, RV dilatation, and the MAGGIC score (HR: 1.166, 95 % CI 1.077-1.263, p < 0.001) and for short-term mortality, sPESI and the MAGGIC score (HR: 1.925, 95 % CI 1.243-2.983, p:0.003) were found to be independent predictors for adverse outcomes in patients with acute PE.
CONCLUSIONS: Our study demonstrates that the MAGGIC score can be applied as a valuable prognostic tool for acute pulmonary embolism.
摘要：
目的：急性肺栓塞（PE）是一种潜在的危及生命的疾病，其特征是肺动脉突然阻塞。尽管MAGGIC风险评分已成为预测慢性心力衰竭患者预后的有价值的工具，它也已被证明并确定为心力衰竭以外的各种心脏疾病的预后模型.在这项研究中,我们旨在探讨MAGGIC评分与PE患者不良结局之间的关系.
方法：本研究回顾性纳入了302例诊断为急性PE的连续患者。对于每个病人来说,计算MAAGGIC评分.根据MAGGIC评分的中位数将研究人群分为两组。
结果：MAGGIC评分高的患者在老年人和女性中的比例明显更高，较低的BMI,CAD的存在更高，DM,AFib，HF,HT,CKD,COPD,以及ACEI/ARB和NOAC的使用。使用单变量和多变量分析进行Logistic回归分析，以预测纳入的PE患者的院内和30天死亡率预测因子。对于住院死亡率，舒张压,心率,RV扩张,MAGGIC评分（HR：1.166，95%CI1.077-1.263，p<0.001）和短期死亡率，sPESI和MAGGIC评分(HR:1.925,95%CI1.243-2.983,p:0.003)是急性PE患者不良结局的独立预测因子。
结论：我们的研究表明，MAGGIC评分可以作为急性肺栓塞的一个有价值的预后工具。
方法：本研究回顾性纳入了302例诊断为急性PE的连续患者。对于每个病人来说,计算MAAGGIC评分.根据MAGGIC评分的中位数将研究人群分为两组。
结果：MAGGIC评分高的患者在老年人和女性中的比例明显更高，较低的BMI,CAD的存在更高，DM,AFib，HF,HT,CKD,COPD,以及ACEI/ARB和NOAC的使用。使用单变量和多变量分析进行Logistic回归分析，以预测纳入的PE患者的院内和30天死亡率预测因子。对于住院死亡率，舒张压,心率,RV扩张,MAGGIC评分（HR：1.166，95%CI1.077-1.263，p<0.001）和短期死亡率，sPESI和MAGGIC评分(HR:1.925,95%CI1.243-2.983,p:0.003)是急性PE患者不良结局的独立预测因子。
结论：我们的研究表明，MAGGIC评分可以作为急性肺栓塞的一个有价值的预后工具。
