Abstract：
Neutrophil extracellular traps (NETs) are web-like structures composed of cytoplasmic contents, DNA chromatin and various granular proteins released by neutrophils in response to viruses, bacteria, immune complexes and cytokines. Studies have shown that NETs can promote the occurrence, development and metastasis of tumors. In this paper, the mechanism underlying the formation and degradation of NETs and the malignant biological behaviors of NETs, such as the promotion of tumor cell proliferation, epithelial mesenchymal transition, extracellular matrix remodeling, angiogenesis, immune evasion and tumor-related thrombosis, are described in detail. NETs are being increasingly studied as therapeutic targets for tumors. We have summarized strategies for targeting NETs or interfering with NET-cancer cell interactions and explored the potential application value of NETs as biomarkers in cancer diagnosis and treatment, as well as the relationship between NETs and therapeutic resistance.
摘要：
中性粒细胞胞外陷阱（NETs）是由细胞质内容物组成的网状结构，DNA染色质和各种颗粒蛋白释放的中性粒细胞响应病毒，细菌,免疫复合物和细胞因子。研究表明，NET可以促进其发生，肿瘤的发展和转移。在本文中,NETs形成和降解的潜在机制以及NETs的恶性生物学行为，如促进肿瘤细胞增殖，上皮间质转化，细胞外基质重塑，血管生成,免疫逃避和肿瘤相关的血栓形成，有详细描述。NET作为肿瘤的治疗靶标正被越来越多地研究。我们总结了靶向NETs或干扰NETs与癌细胞相互作用的策略，并探讨了NETs作为生物标志物在癌症诊断和治疗中的潜在应用价值。以及NETs与治疗抗性之间的关系。
