Abstract：
Information on the physical compatibility of intravenous (IV) medications is vital for patient care and safety in acute care settings. Drug information resources list ondansetron and nafcillin as IV compatible, however, bolus concentrations of ondansetron are not reported. This study investigated the in vitro physical compatibility of bolus and infusion concentrations of ondansetron hydrochloride with nafcillin sodium. Two admixtures were prepared: 1) ondansetron hydrochloride 2 mg/mL and nafcillin sodium 20 mg/mL, and 2) ondansetron hydrochloride 0.16 mg/mL and nafcillin sodium 20 mg/mL. The admixtures were prepared in triplicate using aseptic technique according to manufacturer guidance and stored at room temperature (22-23 °C) for up to 24 hours. Admixtures were examined for visual precipitation, turbidity, and pH at baseline and at 1, 5, 8, and 24 hours. Admixture 1 developed a haze immediately after mixing, which was sustained over 24 hours. There was a demonstrative change in absorbance after 1 hour, but pH remained stable until hour 24. Admixture 2 developed a haze at 5 hours, but the absorbance and pH remained stable until hour 24; a decrease in the pH was observed in all samples at hour 24. This in vitro study revealed that ondansetron hydrochloride 2 mg/mL and nafcillin sodium 20 mg/mL are not physically compatible when administered through the same IV line. No demonstrative change was observed with ondansetron hydrochloride 0.16 mg/mL and nafcillin sodium 20 mg/mL; however, concurrent administration of these medications is questionable when delivered through an IV line for periods of five hours or longer.
摘要：
关于静脉（IV）药物的物理相容性的信息对于急性护理环境中的患者护理和安全至关重要。药物信息资源列出昂丹司琼和纳夫西林为IV兼容，然而,没有报道昂丹司琼的推注浓度。这项研究研究了推注和输注浓度的盐酸昂丹司琼与纳夫西林钠的体外物理相容性。制备了两种混合物：1）盐酸昂丹司琼2mg/mL和纳夫西林钠20mg/mL，和2)盐酸昂丹司琼0.16mg/mL和萘夫西林钠20mg/mL。根据制造商指导使用无菌技术一式三份制备混合物,并在室温(22-23°C)下储存长达24小时。检查混合物的视觉沉淀，浊度,和在基线和1、5、8和24小时时的pH。混合物1在混合后立即出现浑浊，持续了24小时。1小时后，吸光度出现明显变化，但pH值保持稳定直到24小时。混合物2在5小时时出现浑浊，但是吸光度和pH保持稳定直到24小时;在24小时在所有样品中观察到pH的降低。这项体外研究表明，当通过相同的IV线给药时，盐酸昂丹司琼2mg/mL和萘夫西林钠20mg/mL在物理上不相容。盐酸昂丹司琼0.16mg/mL和萘夫西林钠20mg/mL未观察到明显变化；然而，当通过静脉给药线给药5小时或更长时间时,这些药物的同时给药是有问题的.
