PDF(Pubmed)
Abstract：
Memories of events are linked to the contexts in which they were encoded. This contextual linking ensures enhanced access to those memories that are most relevant to the context at hand, including specific associations that were previously learned in that context. This principle, referred to as encoding specificity, predicts that context-specific neural states should bias retrieval of particular associations over others, potentially allowing for the disambiguation of retrieval cues that may have multiple associations or meanings. Using a context-odor paired associate learning paradigm in mice, here, we show that chemogenetic manipulation of dentate gyrus ensembles corresponding to specific contexts reinstates context-specific neural states in downstream CA1 and biases retrieval toward context-specific associations.
摘要：
事件的记忆与它们被编码的上下文相关联。这种上下文链接可确保增强对与当前上下文最相关的记忆的访问，包括以前在这种情况下学习的特定关联。这个原则,称为编码特异性，预测特定于上下文的神经状态应该偏向于对特定关联的检索，可能允许对可能具有多种关联或含义的检索提示进行歧义消除。在小鼠中使用上下文-气味配对的关联学习范式，在这里，我们表明，对应于特定上下文的齿状回集合的化学遗传学操作可恢复下游CA1中上下文特定的神经状态，并使检索偏向上下文特定的关联。
