Abstract：
UNASSIGNED: To evaluate if self-administered bladder neuromodulation with transcutaneous tibial nerve stimulation can safely replace overactive bladder medications in people with spinal cord injury.
UNASSIGNED: We performed a 3-month, randomized, investigator-blinded, tibial nerve stimulation vs sham-control trial in adults with spinal cord injury and neurogenic bladder performing intermittent catheterization and taking overactive bladder medications. The primary outcome was a reduction in bladder medications while maintaining stable bladder symptoms and quality of life based on pre-post Neurogenic Bladder Symptom Score and the Incontinence-QOL questionnaire, respectively. Secondary outcomes included changes in pre-post cystometrogram, 2-day voiding diaries, and an anticholinergic medication side effect survey.
UNASSIGNED: Fifty people consented to the study, with 42 completing the trial. No dropouts were due to stimulation issues. All baseline demographics and surveys were comparable at baseline. Cystometrogram parameters were also comparable at baseline, except the stimulation group had a higher proportion of loss of bladder compliance compared to the control group. At the end of the trial, a significantly greater percentage of the tibial nerve stimulation group were able to reduce medications (95% v 68%), by a 26.2% difference in medication reduction (95% confidence interval 1.17%-51.2%). Function and quality of life surveys and cystometrograms at the end of the trial were alike between groups. Transcutaneous tibial nerve stimulation satisfaction surveys and adherence to protocol were high.
UNASSIGNED: In people with chronic spinal cord injury performing intermittent catheterization, transcutaneous tibial nerve stimulation can be an option to reduce or replace overactive bladder medications.
UNASSIGNED: We performed a 3-month, randomized, investigator-blinded, tibial nerve stimulation vs sham-control trial in adults with spinal cord injury and neurogenic bladder performing intermittent catheterization and taking overactive bladder medications. The primary outcome was a reduction in bladder medications while maintaining stable bladder symptoms and quality of life based on pre-post Neurogenic Bladder Symptom Score and the Incontinence-QOL questionnaire, respectively. Secondary outcomes included changes in pre-post cystometrogram, 2-day voiding diaries, and an anticholinergic medication side effect survey.
UNASSIGNED: Fifty people consented to the study, with 42 completing the trial. No dropouts were due to stimulation issues. All baseline demographics and surveys were comparable at baseline. Cystometrogram parameters were also comparable at baseline, except the stimulation group had a higher proportion of loss of bladder compliance compared to the control group. At the end of the trial, a significantly greater percentage of the tibial nerve stimulation group were able to reduce medications (95% v 68%), by a 26.2% difference in medication reduction (95% confidence interval 1.17%-51.2%). Function and quality of life surveys and cystometrograms at the end of the trial were alike between groups. Transcutaneous tibial nerve stimulation satisfaction surveys and adherence to protocol were high.
UNASSIGNED: In people with chronic spinal cord injury performing intermittent catheterization, transcutaneous tibial nerve stimulation can be an option to reduce or replace overactive bladder medications.
摘要：
■评估经皮胫神经刺激的自我膀胱神经调节是否可以安全地替代脊髓损伤患者的膀胱过度活动症药物。
■我们进行了3个月，随机化，调查员失明，在患有脊髓损伤和神经源性膀胱的成人中，进行间歇性导管插入和服用膀胱过度活动药物的胫骨神经刺激与假对照试验。主要结果是根据神经源性膀胱症状评分和尿失禁生活质量问卷，减少膀胱药物，同时保持稳定的膀胱症状和生活质量。分别。次要结果包括膀胱造影前的变化，2天作废日记,和抗胆碱能药物副作用调查。
■50人同意这项研究，42完成审判。没有因刺激问题而辍学。所有基线人口统计学和调查在基线时具有可比性。基线时的膀胱频谱图参数也相当，与对照组相比，除了刺激组的膀胱顺应性丧失比例更高。审判结束时,胫骨神经刺激组能够减少药物治疗的百分比明显更高（95％v68％），通过26.2％的药物减少差异（95％置信区间1.17％-51.2％）。试验结束时的功能和生活质量调查以及膀胱造影在组间相似。经皮胫神经刺激满意度调查和对方案的依从性很高。
■对慢性脊髓损伤患者进行间歇性导尿，经皮胫神经刺激可以减少或替代膀胱过度活动症药物。
■我们进行了3个月，随机化，调查员失明，在患有脊髓损伤和神经源性膀胱的成人中，进行间歇性导管插入和服用膀胱过度活动药物的胫骨神经刺激与假对照试验。主要结果是根据神经源性膀胱症状评分和尿失禁生活质量问卷，减少膀胱药物，同时保持稳定的膀胱症状和生活质量。分别。次要结果包括膀胱造影前的变化，2天作废日记,和抗胆碱能药物副作用调查。
■50人同意这项研究，42完成审判。没有因刺激问题而辍学。所有基线人口统计学和调查在基线时具有可比性。基线时的膀胱频谱图参数也相当，与对照组相比，除了刺激组的膀胱顺应性丧失比例更高。审判结束时,胫骨神经刺激组能够减少药物治疗的百分比明显更高（95％v68％），通过26.2％的药物减少差异（95％置信区间1.17％-51.2％）。试验结束时的功能和生活质量调查以及膀胱造影在组间相似。经皮胫神经刺激满意度调查和对方案的依从性很高。
■对慢性脊髓损伤患者进行间歇性导尿，经皮胫神经刺激可以减少或替代膀胱过度活动症药物。
