Abstract：
Oral ulcers induce acute weight loss due to anorexia in foot-and-mouth disease virus (FMDV) infected cattle. We hypothesized that providing a palatable form of a therapeutic diet (TD) in different physical forms would increase the feed intake, digestibility and restoration of body weight. A TD was formulated with 19% CP and 2.9 Mcal ME/kg on dry matter basis. Bull calves of 10-12 months with mean body weight of 123 ± 1.3 kg were experimentally infected with FMDV (n = 18) and offered one of the following three forms of the TD (n = 6/group) for 6 weeks post-FMDV infection (WPI): (i) TD in mash form (TDM) (ii) TD in cooked form (TDC) and (iii) TDC + customised nutrient supplement (TDCNS) such as Zn, Cu, Cr, Mn, and Se. The CNS was fed before the TDC. A group of uninfected control (n = 4) was fed TDM. Green fodder was offered in the afternoon. Dry matter intake (DMI) of TD and green fodder were recorded at 24 h interval till WPI 6. Body weight (BW) was recorded at weekly interval. Digestibility trial was conducted at WPI 6. The palatability of the TD was scored from 1- 4 and healing of tongue ulcers was analyzed by Kaplan-Meier survival curve. The results indicated that the physical form of TD increased the total DMI by WPI 3, which was supported by the restoration of BW and higher palatability score. The digestibility of all the proximate principles except EE was significantly higher (P < 0.05) in the groups that were fed TDC. It was concluded that feeding TD irrespective of the physical form, restored the ADG and DMI in the calves by WPI 3. Further, feeding cooked form of TD increased the digestibility in the FMDV infected calves and supplementation of CNS hastened the healing of glossal ulcers.
摘要：
口腔溃疡在口蹄疫病毒（FMDV）感染的牛中由于厌食引起急性体重减轻。我们假设以不同的物理形式提供可口的治疗性饮食（TD）会增加采食量，消化率和体重的恢复。TD配制为基于干物质的19%CP和2.9McalME/kg。10-12个月，平均体重为123±1.3kg的牛小牛在实验上感染了FMDV（n=18），并在FMDV感染（WPI）后6周提供了以下三种形式的TD（n=6/组）：（i）糊状TD（TDM）（ii）煮熟的TD（TDC）和（iii）TDC定制营养补充剂（TDC）Cu,Cr,Mn,还有Se。CNS在TDC之前进料。一组未感染的对照(n=4)饲喂TDM。绿色饲料在下午提供。以24小时的间隔记录TD和绿色饲料的干物质摄入量（dryi），直到WPI6。以每周间隔记录体重(BW)。消化性试验在WPI6进行。TD的适口性从1-4评分，并通过Kaplan-Meier生存曲线分析舌头溃疡的愈合。结果表明，TD的物理形式使WPI3增加了总MI，这得到了BW的恢复和更高的适口性评分的支持。在饲喂TDC的组中,除EE之外的所有近似原则的消化率显著较高(P<0.05)。结论是，无论物理形式如何，喂食TD，WPI3恢复了小牛的ADG和QI。Further,饲喂煮熟的TD增加了FMDV感染的小牛的消化率，补充CNS加速了舌管溃疡的愈合。
