PDF(Pubmed)
Abstract：
Anesthetic-induced developmental neurotoxicity (AIDN) can arise due to various factors, among which aberrant nerve cell death is a prominent risk factor. Animal studies have reported that repeated or prolonged anesthetic exposure can cause significant neuroapoptosis in the developing brain. Lately, non-apoptotic programmed cell deaths (PCDs), characterized by inflammation and oxidative stress, have gained increasing attention. Substantial evidence suggests that non-apoptotic PCDs are essential for neuronal cell death in AIDN compared to apoptosis. This article examines relevant publications in the PubMed database until April 2024. Only original articles in English that investigated the potential manifestations of non-apoptotic PCD in AIDN were analysed. Specifically, it investigates necroptosis, pyroptosis, ferroptosis, and parthanatos, elucidating the signaling mechanisms associated with each form. Furthermore, this study explores the potential relevance of these non-apoptotic PCDs pathways to the pathological mechanisms underlying AIDN, drawing upon their distinctive characteristics. Despite the considerable challenges involved in translating fundamental scientific knowledge into clinical therapeutic interventions, this comprehensive review offers a theoretical foundation for developing innovative preventive and treatment strategies targeting non-apoptotic PCDs in the context of AIDN.
摘要：
麻醉诱导的发育神经毒性（AIDN）可能由于各种因素而出现，其中异常神经细胞死亡是一个突出的危险因素。动物研究报告说，反复或长时间的麻醉剂暴露会导致发育中的大脑发生明显的神经细胞凋亡。最近,非凋亡性程序性细胞死亡（PCDs），以炎症和氧化应激为特征，得到了越来越多的关注。大量证据表明，与凋亡相比，非凋亡性PCD对于AIDN中的神经元细胞死亡至关重要。本文研究了截至2024年4月的PubMed数据库中的相关出版物。仅分析了研究AIDN中非凋亡性PCD潜在表现的英文原始文章。具体来说,它研究坏死，焦亡,铁性凋亡,和parthanatos,阐明与每种形式相关的信号机制。此外，本研究探讨了这些非凋亡PCDs通路与AIDN潜在病理机制的潜在相关性，借鉴其鲜明的特点。尽管在将基础科学知识转化为临床治疗干预措施方面存在相当大的挑战，本综述为在AIDN背景下开发针对非凋亡性PCDs的创新预防和治疗策略提供了理论基础.
