Abstract：
Acute nociceptive pain in mice caused by subcutaneous (intraplantar) injection of TRPV1 ion channel agonist capsaicin (1.6 μg/mouse) and the effects of protein kinase A inhibitor H-89 (0.05 mg/mouse, intraplantar injection) and NMDA receptor channel antagonists MK-801 (7.5 and 15 μg/mouse, topical application) and hemantane (0.5 mg/mouse, topical application) on the pain were assessed. MK-801 and hemantane were found to reduce the duration of the pain response. H-89 did not significantly affect the pain in animals, but preliminary administration of this drug abolished the antinociceptive effect of MK-801 (7.5 μg/mouse) and weakens the effect of hemantane (0.5 mg/mouse).
摘要：
皮下（足底内）注射TRPV1离子通道激动剂辣椒素（1.6μg/小鼠）引起的小鼠急性伤害性疼痛和蛋白激酶A抑制剂H-89（0.05mg/小鼠，足底内注射）和NMDA受体通道拮抗剂MK-801（7.5和15μg/小鼠，局部应用）和hemantane（0.5mg/小鼠，局部应用）对疼痛进行了评估。发现MK-801和hemantane可减少疼痛反应的持续时间。H-89对动物的疼痛没有显著影响,但是该药物的初步施用消除了MK-801（7.5μg/小鼠）的镇痛作用，并削弱了hemantane（0.5mg/小鼠）的作用。
