Abstract：
The study revealed no effects of pregnancy and childbirth on the course of tuberculosis in female BALB/c mice after aerosol infection with Mycobacterium tuberculosis. However, we demonstrated a negative effect of tuberculosis infection on the fertility of infected females, which manifested in a longer period from mating to pregnancy and in a smaller litter size. Impaired reproductive function in response to the effect of the systemic infectious process was accompanied by the development of immunosuppression confirmed by an immunological test (delayed-type hypersensitivity to tuberculin) and the formation of genital tract dysbiosis during pregnancy and postpartum period.
摘要：
研究表明，在结核分枝杆菌气雾剂感染后，妊娠和分娩对雌性BALB/c小鼠的结核病病程没有影响。然而,我们证明了结核病感染对感染女性的生育能力有负面影响，表现在从交配到怀孕的较长时期和较小的产仔数。响应于全身感染过程的影响而受损的生殖功能伴随着免疫抑制的发展，该免疫抑制通过免疫学测试（对结核菌素的迟发型超敏反应）和在怀孕和产后期间形成生殖道菌群失调。
