Abstract：
Frank\'s sign (FS, earlobe crease) is known to be associated with many chronic diseases i.e. coronary, cerebrovascular, and peripheral vascular diseases. The objective of this study is to investigate the presence and grade of FS in healthy, young-adult individuals aging between 18 and 25. Furthermore, to evaluate the relationship between FS and the chronic disease history of first-degree family members. 853 healthy people with a mean age of 20.09 years were imvolved in the research on a voluntary basis. Of 853 individuals, 85.3% (n:728) had no FS, whereas 14.7% (n:125) had. Of the 125 people observed FS, 41.6% (n:52) were female and 58.4% (n:73) were male. Of the 125 people diagnosed with FS, 32.8% (n:41) had no family history of any chronic disease, and 67.2% (n:84) had at least 1 family history of chronic disease as well. It was determined that there was a statistically significant (p < 0.05) relationship between FS identified in healthy individuals and familial chronic disease history. In this study, while no FS was observed in 85.3% of the participants, grade 1 was detected in 12.4% (n:105), grade 2a in 1.9% (n:16), grade 2b in 0.2% (n:2), and grade 3 in 0.2% (n:2). To the best of our knowledge, this study investigated the relationship between the presence and grade of FS in the healthy, young, Turkish population and the presence/absence of chronic disease in the first-degree relatives of individuals for the very first time. As a result of larger studies, being aware of the presence of FS, especially in young healthy individuals, may help predict some chronic diseases, and caution may be taken to avoid these diseases at an early age in at-risk individuals.
摘要：
弗兰克的标志(FS，耳垂折痕)已知与许多慢性疾病相关，即冠状动脉，脑血管,和外周血管疾病。这项研究的目的是调查健康人群中FS的存在和等级，年龄在18至25岁之间的年轻人。此外，评估FS与一级家庭成员慢性病史的关系。853名平均年龄为20.09岁的健康人自愿参与了这项研究。853人中,85.3%(n:728)没有FS，而14.7%（n：125）有。在125名观察到FS的人中，41.6%(n:52)为女性,58.4%(n:73)为男性。在被诊断为FS的125人中，32.8%(n:41)无慢性病家族史,67.2％（n：84）也有至少1个慢性病家族史。确定在健康个体中鉴定的FS与家族性慢性病史之间存在统计学上显著(p<0.05)的关系。在这项研究中,虽然85.3%的参与者没有观察到FS，在12.4%(n:105)中检测到1级，2a级1.9%(n:16)，2b级为0.2%(n:2)，和等级3为0.2%（n：2）。据我们所知,这项研究调查了健康人群中FS的存在与等级之间的关系，年轻,土耳其人口和个人一级亲属中慢性病的存在/不存在第一次。作为更大规模研究的结果，知道FS的存在，尤其是在年轻的健康个体中，可能有助于预测一些慢性疾病，和谨慎，以避免这些疾病在早期的风险个体。
