Abstract：
UNASSIGNED: Allergic Rhinitis (AR), a prevalent condition in otorhinolaryngology, is mediated by Type 1 hypersensitivity through IgE, characterized by Type 2 inflammatory response and eosinophil infiltration in the nasal mucosa. Since AR disease exhibits significant heterogeneity in symptom severity, an objective assessment of AR severity may facilitate better individualized treatment.
UNASSIGNED: To explore the changes in peripheral blood IL-9, Th9, and BAFF levels of allergic rhinitis (AR) in patients and the clinical significance associated with it.
UNASSIGNED: A retrospective study selected 80 AR patients admitted from January 2022 to October 2022 as the case group, dividing them into mild and moderate-to-severe groups based on symptom scores. Concurrently, 50 patients without AR, who were treated for nasal bone fractures or underwent septoplasty, were selected as the group for comparison. Alterations in the expression levels of peripheral blood IL-9, Th9, and BAFF were analyzed and compared among the different groups. The diagnostic value of serum BAFF for the severity of AR was analyzed using the receiver operating characteristic (ROC) curve.
UNASSIGNED: Noticeable variations were observed in clinical variables among the three groups such as, total IgE levels, peripheral blood eosinophil count and proportion, TNSS, and VAS (P< 0.05), while no statistically significant differences were observed in other variables (P> 0.05). The comparison of IL-9, Th9, and BAFF among the three groups revealed statistically significant differences (P< 0.05). Analysis using multivariate logistic regression revealed that IL-9 (OR = 2.365), Th9 (OR = 2.186), BAFF (OR = 2.307) were influencing factors of moderate-to-severe AR (P< 0.05). The ROC curve indicated that the AUC for the diagnosis of moderate-to-severe AR by IL-9, Th9, BAFF were 0.770, 0.734, 0.761, respectively, and the combined detection AUC was 0.888, an area under the curve higher than individual testing.
UNASSIGNED: Changes in peripheral blood IL-9, Th9, and BAFF levels in AR patients may function as indicators to assess the level of severity in diagnostic procedures.
UNASSIGNED: To explore the changes in peripheral blood IL-9, Th9, and BAFF levels of allergic rhinitis (AR) in patients and the clinical significance associated with it.
UNASSIGNED: A retrospective study selected 80 AR patients admitted from January 2022 to October 2022 as the case group, dividing them into mild and moderate-to-severe groups based on symptom scores. Concurrently, 50 patients without AR, who were treated for nasal bone fractures or underwent septoplasty, were selected as the group for comparison. Alterations in the expression levels of peripheral blood IL-9, Th9, and BAFF were analyzed and compared among the different groups. The diagnostic value of serum BAFF for the severity of AR was analyzed using the receiver operating characteristic (ROC) curve.
UNASSIGNED: Noticeable variations were observed in clinical variables among the three groups such as, total IgE levels, peripheral blood eosinophil count and proportion, TNSS, and VAS (P< 0.05), while no statistically significant differences were observed in other variables (P> 0.05). The comparison of IL-9, Th9, and BAFF among the three groups revealed statistically significant differences (P< 0.05). Analysis using multivariate logistic regression revealed that IL-9 (OR = 2.365), Th9 (OR = 2.186), BAFF (OR = 2.307) were influencing factors of moderate-to-severe AR (P< 0.05). The ROC curve indicated that the AUC for the diagnosis of moderate-to-severe AR by IL-9, Th9, BAFF were 0.770, 0.734, 0.761, respectively, and the combined detection AUC was 0.888, an area under the curve higher than individual testing.
UNASSIGNED: Changes in peripheral blood IL-9, Th9, and BAFF levels in AR patients may function as indicators to assess the level of severity in diagnostic procedures.
摘要：
■过敏性鼻炎（AR），耳鼻咽喉科的普遍状况，通过IgE由1型超敏反应介导，以鼻粘膜中的2型炎症反应和嗜酸性粒细胞浸润为特征。由于AR疾病在症状严重程度上表现出显著的异质性，对AR严重程度的客观评估可能有助于更好的个体化治疗.
■探讨变应性鼻炎（AR）患者外周血IL-9，Th9和BAFF水平的变化及其临床意义。
■一项回顾性研究选择了2022年1月至2022年10月收治的80例AR患者作为病例组，根据症状评分将其分为轻度和中度至重度组。同时,50例患者无AR，接受鼻骨骨折治疗或接受鼻中隔成形术的人，选择作为比较组。分析并比较不同组间外周血IL-9、Th9和BAFF表达水平的变化。采用受试者工作特征(ROC)曲线分析血清BAFF对AR严重程度的诊断价值。
■在三组的临床变量中观察到明显的差异，例如，总IgE水平,外周血嗜酸性粒细胞计数和比例，TNSS,和VAS（P<0.05），而其他变量无统计学差异(P>0.05)。三组间IL-9、Th9、BAFF比较差异有统计学意义(P<0.05)。多因素Logistic回归分析显示IL-9(OR=2.365)、Th9（OR=2.186），BAFF(OR=2.307)是中重度AR的影响因素(P<0.05)。ROC曲线显示IL-9、Th9、BAFF诊断中重度AR的AUC分别为0.770、0.734、0.761,联合检测AUC为0.888，曲线下面积高于单独检测。
■AR患者外周血IL-9，Th9和BAFF水平的变化可能作为评估诊断程序严重程度的指标。
■探讨变应性鼻炎（AR）患者外周血IL-9，Th9和BAFF水平的变化及其临床意义。
■一项回顾性研究选择了2022年1月至2022年10月收治的80例AR患者作为病例组，根据症状评分将其分为轻度和中度至重度组。同时,50例患者无AR，接受鼻骨骨折治疗或接受鼻中隔成形术的人，选择作为比较组。分析并比较不同组间外周血IL-9、Th9和BAFF表达水平的变化。采用受试者工作特征(ROC)曲线分析血清BAFF对AR严重程度的诊断价值。
■在三组的临床变量中观察到明显的差异，例如，总IgE水平,外周血嗜酸性粒细胞计数和比例，TNSS,和VAS（P<0.05），而其他变量无统计学差异(P>0.05)。三组间IL-9、Th9、BAFF比较差异有统计学意义(P<0.05)。多因素Logistic回归分析显示IL-9(OR=2.365)、Th9（OR=2.186），BAFF(OR=2.307)是中重度AR的影响因素(P<0.05)。ROC曲线显示IL-9、Th9、BAFF诊断中重度AR的AUC分别为0.770、0.734、0.761,联合检测AUC为0.888，曲线下面积高于单独检测。
■AR患者外周血IL-9，Th9和BAFF水平的变化可能作为评估诊断程序严重程度的指标。
