PDF(Pubmed)
Abstract：
TMEM16 proteins, which function as Ca2+‑activated Cl‑ channels are involved in regulating a wide variety of cellular pathways and functions. The modulators of Cl‑ channels can be used for the molecule‑based treatment of respiratory diseases, cystic fibrosis, tumors, cancer, osteoporosis and coronavirus disease 2019. The TMEM16 proteins link Ca2+ signaling, cellular electrical activity and lipid transport. Thus, deciphering these complex regulatory mechanisms may enable a more comprehensive understanding of the physiological functions of the TMEM16 proteins and assist in ascertaining the applicability of these proteins as potential pharmacological targets for the treatment of a range of diseases. The present review examined the structures, functions and characteristics of the different types of TMEM16 proteins, their association with the pathogenesis of various diseases and the applicability of TMEM16 modulator‑based treatment methods.
摘要：
TMEM16蛋白,作为Ca2激活的Cl通道起作用，参与调节多种细胞途径和功能。Cl通道的调节剂可用于基于分子的呼吸系统疾病治疗，囊性纤维化,肿瘤，癌症,骨质疏松症和冠状病毒病2019。TMEM16蛋白连接Ca2+信号，细胞电活动和脂质运输。因此，破译这些复杂的调节机制可以更全面地了解TMEM16蛋白的生理功能,并有助于确定这些蛋白作为治疗一系列疾病的潜在药理学靶点的适用性.本审查审查了这些结构，不同类型的TMEM16蛋白的功能和特性，它们与各种疾病的发病机制以及基于TMEM16调节剂的治疗方法的适用性有关。
