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Abstract：
The Hippo signaling pathway plays a pivotal role in regulating cell growth and organ size. Its regulatory effects on hepatocellular carcinoma (HCC) encompass diverse aspects, including cell proliferation, invasion and metastasis, tumor drug resistance, metabolic reprogramming, immunomodulatory effects and autophagy. Yes‑associated protein 1 (YAP1), a potent transcriptional coactivator and a major downstream target tightly controlled by the Hippo pathway, is influenced by various molecules and pathways. The expression of YAP1 in different cell types within the liver tumor microenvironment exerts varying effects on tumor outcomes, warranting careful consideration. Therefore, research on YAP1‑targeted therapies merits attention. This review discusses the composition and regulation mechanism of the Hippo/YAP1 signaling pathway and its relationship with HCC, offering insights for future research and cancer prevention strategies.
摘要：
Hippo信号通路在调节细胞生长和器官大小方面起着关键作用。其对肝细胞癌（HCC）的调节作用包括不同方面，包括细胞增殖，侵袭和转移，肿瘤耐药，代谢重编程，免疫调节作用和自噬。是相关蛋白1（YAP1），一种有效的转录共激活因子和由Hippo途径严格控制的主要下游靶标，受各种分子和途径的影响。YAP1在肝肿瘤微环境中不同细胞类型的表达对肿瘤预后产生不同的影响。值得仔细考虑。因此,对YAP1靶向疗法的研究值得关注。本文综述了Hippo/YAP1信号通路的组成和调控机制及其与肝癌的关系,为未来的研究和癌症预防策略提供见解。
