盐皮质激素受体 ( MR ) 拮抗剂依普利酮和 MR 调节剂巴辛烯酮通过 MR / 蛋白聚糖 / TLR4 途径预防肾脏细胞外基质重塑和炎症。
关键词: balcinrenone chronic kidney disease inflammation mineralocorticoid receptor renal fibrosis toll-like receptors
Mesh : Animals Mineralocorticoid Receptor Antagonists / pharmacology therapeutic use Toll-Like Receptor 4 / metabolism Eplerenone / pharmacology therapeutic use Receptors, Mineralocorticoid / metabolism Extracellular Matrix / metabolism drug effects Signal Transduction / drug effects Male Mice, Inbred C57BL Proteoglycans / metabolism Spironolactone / pharmacology analogs & derivatives Renal Insufficiency, Chronic / drug therapy metabolism pathology Disease Models, Animal Kidney / drug effects metabolism pathology Mice Inflammation / metabolism drug therapy