PDF(Pubmed)
Abstract：
Numerous studies have demonstrated the rise in neurological and psychiatric issues linked to post-COVID-19 infections. The most prevalent symptoms include encephalopathy, seizures, depression, anxiety, and ischemic or hemorrhagic stroke. The occurrence of Creutzfeldt-Jakob disease (CJD) after COVID-19 was unusual, but recent studies have shown a connection between COVID-19 and prion disease. Most cases of CJD present within weeks or a few months after the onset of COVID-19. The late onset of Creutzfeldt-Jakob disease following the COVID-19 infection raises questions about the potential pathophysiological mechanisms underlying this association. Although the exact link remains elusive, this case adds to the growing body of evidence suggesting a possible relationship between COVID-19 and neurodegenerative diseases. Further research is warranted to elucidate the underlying mechanisms and optimize management strategies for post-COVID-19 neurological complications. We present to you an 83-year-old man with a history of COVID-19 infection who presents with memory impairment, mood instability, and declining cognitive function. Despite initial improvement, his condition rapidly deteriorated, ultimately leading to a diagnosis of probable Creutzfeldt-Jakob disease.
摘要：
许多研究表明，与COVID-19后感染相关的神经和精神问题的增加。最常见的症状包括脑病，癫痫发作,抑郁症,焦虑,缺血性或出血性中风。COVID-19后出现克雅氏病（CJD）并不常见，但最近的研究表明COVID-19与朊病毒病之间存在联系。大多数CJD病例在COVID-19发病后几周或几个月内出现。COVID-19感染后，克雅氏病的晚期发作引发了人们对这种关联的潜在病理生理机制的质疑。尽管确切的联系仍然难以捉摸，这一病例增加了越来越多的证据，表明COVID-19与神经退行性疾病之间可能存在关系。需要进一步的研究来阐明COVID-19后神经系统并发症的潜在机制并优化管理策略。我们向您介绍一名83岁的有COVID-19感染史的男子，他表现为记忆障碍，情绪不稳定,认知功能下降。尽管初步改善,他的病情迅速恶化，最终导致可能的克雅氏病的诊断。
